急性冠脉综合征患者应用丹参多酚酸与氯吡格雷联合治疗的疗效研究

Efficacy of Salvia Miltiorrhiza Polyphenolic Acid Combined with Clopidogrel in Patients with Acute Coronary Syndrome

目的:探讨急性冠脉综合征(ACS)患者应用丹参多酚酸与氯吡格雷联合治疗的疗效及对机体氧化应激损伤的影响。方法:本研究选取116例ACS患者为观察对象,收集时间为2019年3到2021年2月。遵循随机数字表法对所有观察对象分组:对照组(58例)、联合组(58例)。对照组应用氯吡格雷治疗,联合组应用丹参多酚酸与氯吡格雷联合治疗。评价临床疗效,比较治疗前后心功能指标以及氧化应激损伤指标。结果:联合组总有效率较对照组的比较,显著提高(93.10%VS 79.31%,P<0.05)。治疗后,两组LVEDD、LVESD降低,LVEF升高(P<0.05)。联合组治疗后LVEF高于对照组,LVEDD、LVESD低于对照组(P<0.05)。治疗后,两组GSH-Px、SOD水平升高,MDA水平降低(P<0.05)。联合组治疗后GSH-Px、SOD水平高于对照组,MDA水平低于对照组(P<0.05)。结论:ACS患者应用丹参多酚酸与氯吡格雷联合治疗取得的疗效确切,患者心功能得到改善,可以抑制机体氧化应激损伤,具有较高的临床推广价值。

Objective:To investigate the effect of Salvia miltiorrhiza polyphenolic acid combined with clopidogrel on oxidative stress injury in patients with acute coronary syndrome(ACS).Method:In this study,116 patients with ACS were selected for observation.The collection time was from March 2019 to February 2021.All subjects were divided into control group(58 cases)and combined group(58 cases)by random number table.The control group was treated with clopidogrel,and the combined group was treated with Salvia miltiorrhiza polyphenolic acid and clopidogrel.The clinical efficacy was evaluated and the indexes of cardiac function and oxidative stress injury were compared before and after treatment.Result:The total effective rate of the combined group was significantly higher than that of the control group(93.10%VS79.31%,P<0.05).After treatment,LVEDd and LVESD decreased and LVEF increased in both groups(P<0.05).After treatment,LVEF in the combined group was higher than that in the control group,and LVEDd and LVESD were lower than those in the control group(P<0.05).After treatment,the levels of GSH PX and SOD increased and MDA decreased in both groups(P<0.05).After treatment,the levels of GSH PX and SOD in the combined group were higher than those in the control group,and the levels of MDA were lower than those in the control group(P<0.05).Conclusion:The combination of Salvia miltiorrhiza polyphenolic acid and clopidogrel in the treatment of ACS patients has a definite effect,the patient's cardiac function has been improved,and the oxidative stress injury can be inhibited.It has a high clinical value.