急性胰腺炎重症患者应用奥曲肽与加贝酯治疗效果研究

Effect of Octreotide and Gabexate on Severe Acute Pancreatitis

目的:观察分析急性胰腺炎重症患者应用奥曲肽与加贝酯治疗的效果。方法:124例急性胰腺炎患者作为本研究的观察对象,来自2018年1月—2020年12月我院收治。按照随机数字表法的原则将其分为两组:研究组和对照组,各有62例患者。所有患者基础治疗均采用常规的对症支持治疗措施,在基础治疗之上对照组应用奥曲肽治疗,研究组应用奥曲肽与加贝酯治疗。所有患者治疗14天,对临床疗效进行评价,比较来自临床症状和体征缓解时间、血清淀粉酶恢复正常时间;治疗前及治疗后检测血清C反应蛋白与清蛋白比值(CAR)、D-二聚体(D-D)、降钙素原(PCT)。结果:研究组治疗总有效率较对照组的显著提高(95.16%VS82.26%,P<0.05)。研究组发热、恶心呕吐、腹痛消失时间及血清淀粉酶水平恢复正常时间均较对照组降低(P<0.05)。两组CAR、PCT及D-D水平治疗后均低于治疗前(P<0.05)。研究组治疗后CAR、PCT及D-D水平较对照组降低显著(P<0.05)。结论:急性胰腺炎重症患者应用奥曲肽与加贝酯治疗的效果确切,患者临床症状及血清淀粉酶水平恢复较快,机体炎症反应水平明显降低,临床大力进行推广的价值较高。

Objective:To observe and analyze the effect of octreotide and gabexate in the treatment of severe acute pancreatitis.Method:124 patients with acute pancreatitis were observed in this study from January 2018 to December 2020.According to the principle of random number table,they were divided into two groups:study group and control group,with 62 patients in each group.All patients were treated with routine symptomatic support measures.On the basis of basic treatment,the control group was treated with octreotide,and the study group was treated with octreotide and gabexate.All patients were treated for 14 days,the clinical efficacy was evaluated,and the relief time of clinical symptoms and signs and the recovery time of serum amylase were compared;The ratio of C-reactive protein to albumin(CAR)、D-Dimer(D-D)and procalcitonin(PCT)were measured before and after treatment.Result:The total effective rate of the study group was significantly higher than that of the control group(95.16%VS 82.26%,P<0.05).The disappearance time of fever,nausea and vomiting,abdominal pain and the recovery time of serum amylase level in the study group were lower than those in the control group(P<0.05).The levels of CAR、PCT and D-D in the two groups after treatment were lower than those before treatment(P<0.05).After treatment,the levels of CAR、PCT and D-D in the study group were significantly lower than those in the control group(P<0.05).Conclusion:Octreotide and gabexate are effective in the treatment of severe acute pancreatitis.Patients'clinical symptoms and serum amylase levels recover rapidly,and the level of body inflammatory response is significantly reduced.Therefore,it is of high value to promote them in clinical practice.