TGM2、CtBP2在胃癌及癌旁组织中的表达及意义分析

Expressions and Significance of TGM2 and CtBP2 in Gastric Cancer and Para-carcinoma Tissues

目的探讨转谷氨酰胺酶2(TGM2)、转录辅阻遏因子2(CtBP2)在胃癌及癌旁组织中的表达及意义。方法收集124例胃癌患者的癌组织和癌旁组织,采用免疫组化染色和半定量积分方法检测TGM2和CtBP2在胃癌及癌旁组织中的表达,并分析其表达与胃癌患者临床病理及预后的关系。结果TGM2和CtBP2在胃癌组织中的表达量高于癌旁组织(P<0.05);TGM2表达水平与肿瘤分化程度、临床分期和淋巴结转移有关(P<0.05),与性别、年龄和肿瘤直径无关(P>0.05);CtBP2表达只与分化程度有关(P<0.05),与性别、年龄、肿瘤直径、临床分期、淋巴结转移无关(P>0.05);TGM2阴性患者3年生存率高于阳性患者(P<0.05),CTBP2阴性患者3年生存率高于阳性患者(P<0.05)。结论TGM2和CtBP2在胃癌组织中的表达率更高,可以作为胃癌疾病早期诊断的标志物;TGM2的表达水平与分化程度、临床分期和淋巴结转移有关,CtBP2的表达只与分化程度有关,TGM2和CtBP2均与患者预后密切相关,可以用于胃癌病情评估和预后判断。

Objective To explore the expressions and significance of transglutaminase-2(TGM2)and C-terminal binding protein 2(CtBP2)in gastric cancer and para-carcinoma tissues.Methods The cancer tissues and para-carcinoma tissues from 124 patients with gastric cancer were collected.The expressions of TGM2 and CtBP2 in gastric cancer and para-carcinoma tissues were detected by immunohistochemical staining and semi-quantitative integral method.And their relationship with clinicopathology and prognosis of gastric cancer patients was analyzed.Results The expression levels of TGM2 and CtBP2 in gastric cancer tissues were higher than those in para-carcinoma tissues(P<0.05).The expression level of TGM2 was related to differentiation degree,clinical staging and lymph node metastasis(P<0.05),while not related to gender,age or tumor diameter(P>0.05).The expression level of CtBP2 was only related to differentiation degree(P<0.05),while not related to gender,age,tumor diameter,clinical staging or lymph node metastasis(P>0.05).The 3-year survival rate in patients with TGM2-negative was higher than that with TGM2-positive(P<0.05),and 3-year survival rate in patients with CTBP2-negative was higher than that with CTBP2-positive(P<0.05).Conclusion The expression rates of TGM2 and CtBP2 are higher in gastric cancer tissues,which can be applied as early diagnosis markers of gastric cancer.The expression level of TGM2 is related to differentiation degree,clinical staging and lymph node metastasis,while expression level of CtBP2 is only related to differentiation degree.Both TGM2 and CtBP2 are closely related to prognosis,which can be applied in condition assessment and prognosis determination of gastric cancer.