Runx2在骨关节炎发生发展中的作用

Role of Runx2 in development of osteoarthritis

骨关节炎(OA)是一种以关节退化或衰老为病理基础,以关节肿胀、疼痛或功能障碍为主要临床表现的常见关节疾病,是导致疼痛和残疾的主要原因之一,然而,目前其发病机制尚不完全明确。OA中Runt相关转录因子2(Runx2)表达升高,Runx2作为调控成骨细胞分化、软骨及骨骼发育的主要转录因子,通过组织及其分子层面与OA进展过程中的不同关节组织(如关节软骨细胞、滑膜细胞、软骨下骨、半月板)相互作用。同时Runx2还可调节细胞外基质降解酶的表达,导致关节软骨细胞外基质合成与分解稳态失衡,在OA的发生发展中扮演重要的角色。

Osteoarthritis is a common joint disease based on joint degeneration or aging,with joint swelling,pain or dysfunction as the main clinical manifestations,and is one of the leading causes of pain and disability worldwide;however,its pathogenesis is not fully understood.It has been found that the expression of Runt-related transcription factor 2(Runx2)is elevated in human osteoarthritis,and Runx2,as a major transcription factor regulating osteoblast differentiation,cartilage and bone development,interacts with different joint tissues during the progression of osteoarthritis,such as articular chondrocytes,synovial cells,subchondral bone and its meniscus,through both from the tissue and its molecular level.Runx2 also regulates the expression of extracellular matrix degrading enzymes,leading to an imbalance in the homeostasis of extracellular matrix synthesis and catabolism in articular cartilage,and plays an important role in the development of osteoarthritis.