结核分枝杆菌诱导宿主Ⅰ型干扰素应答及其免疫调控功能研究进展

Progress of Mycobacterium tuberculosis inducing host type Ⅰ interferon response and immunoregulatory function

阐述结核分枝杆菌感染过程中Ⅰ型干扰素的免疫功能,Ⅰ型干扰素既可以作为活动性结核的标识并加剧结核致病过程,同时也参与机体的抗结核免疫防御过程并降低结核分枝杆菌胞内存活。另外,在不同层面归纳结核分枝杆菌感染诱导宿主Ⅰ型干扰素表达及信号通路活化的机制,并探讨结核分枝杆菌可以通过调控Ⅰ型干扰素应答水平以逃逸宿主免疫,从而促进其在宿主体内持续感染。旨在总结结核分枝杆菌诱导宿主Ⅰ型干扰素应答及其免疫调控功能的研究进展,进而为抗结核药物靶标筛选及疫苗研制提供新思路。

This paper summarizes the immune regulation function of type Ⅰ interferon in the process of Mycobacterium tuberculosis infection. Type Ⅰ interferon can be used as a marker of active tuberculosis and aggravate the pathogenic process of tuberculosis. At the same time, type Ⅰ interferon also participates in the immune defense process of anti-tuberculosis and effectively reduces the intracellular survival of Mycobacterium tuberculosis. In addition, this paper summarizes the mechanism of host type Ⅰ interferon expression and signal pathway activation induced by Mycobacterium tuberculosis infection at different levels, and discussed that some components of Mycobacterium tuberculosis can escape host immunity by regulating the response level of type Ⅰ interferon, so as to promote its survival in the host. The purpose of this paper is to summarize the research progress of host type Ⅰ interferon response induced by Mycobacterium tuberculosis and its immunomodulatory function, so as to provide new ideas for the screening of anti-tuberculosis drug targets and the development of vaccines in the future.