脓毒症的血液净化干预时机

Initiation timing of blood purification therapy in sepsis

脓毒症是临床常见的危重症,其常导致包括肾脏在内的多脏器功能损伤,治疗难度大且病死率高。近年来,体外血液净化治疗在脓毒症治疗领域取得了一定进展,临床上已有多种血液净化治疗模式可以选择,但关于血液净化治疗的干预时机目前尚缺乏统一标准,临床上主要根据患者的肾脏功能替代和/或炎症介质清除2个方面的需求进行血液净化干预指征和时机的评估。该文主要就血液净化治疗在脓毒症中的干预时机作总结和探讨。

Sepsis is a common clinical critical illness,which often leads to multiple organ damage including the kidney damage,which is difficult to treat and has a high mortality rate.In recent years,extracorporeal blood purification therapy has made some progress in the field of sepsis.There are a variety of blood purification modes to choose,but there is still no unified standard for the initiation timing of blood purification therapy.Clinicians mainly evaluate the indicators and the initiation timing of blood purification therapy according to the patient’s needs for renal function replacement and/or inflammatory mediator clearance.This article mainly summarizes and discusses the initiation timing of blood purification therapy in sepsis.