复方甘草酸苷联合阿德福韦酯对乙肝患者血清标志物水平的影响

Effect of compound glycyrrhizin combined with adefovir dipivoxil on the serum marker level in patients with hepatitis B

目的:分析复方甘草酸苷联合阿德福韦酯对乙肝患者血清标志物水平的影响。方法:选取88例乙肝患者,按照随机数字表法分为对照组和观察组,每组各44例。对照组采用阿德福韦酯治疗,观察组在对照组的基础上加用复方甘草酸苷治疗,比较两组乙肝病毒血清标志物、肿瘤坏死因子-α(TNF-α)、生长转化因子(TGF-β1)及不良反应。结果:观察组乙肝e抗体(HBeAb)转阳率、脱氧核糖核酸(HBV-DNA)转阴率、乙肝表面抗原(HBsAg)转阴率及乙肝病毒e抗原(HBeAg)转阴率均高于对照组(P<0.05);TNF-α、TGF-β1水平均低于对照组,两组比较差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:复方甘草酸苷联合阿德福韦酯治疗乙肝,能够降低乙肝病毒活跃度及TNF-α、TGF-β1水平,且具有较高安全性。

Objective:To analyze the effect of compound glycyrrhizin combined with adefovir dipivoxil on serum marker level in patients with hepatitis B.Methods:A total of 88 patients with hepatitis B were randomized into the control group and observation group,each with 44 cases.The control group were given oral adefovir dipivoxil,while the observation group were given compound glycyrrhizin on the basis of the treatment for the control group.The serum marker level of hepatitis B virus,tumor necrosis factor-α(TNF-a),growth transforming factor(TGF-β1)and adverse reactions were compared between the two groups.Results:The conversion rates of hepatitis B e antibody(HBeAb)positive,deoxyribonucleic acid(HBV-DNA)negative,hepatitis B surface antigen(HBsAg)negative and hepatitis B virus e antigen(HBeAg)negative in the observation group were higher than those in the control group;the levels of TNF-αand TGF-β1 were lower than those in the control group,and the difference were statistically significant(P<0.05);there was no statistical significance in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:For patients with hepatitis B,compound glycyrrhizin combined with adefovir dipivoxil can reduce the activity of hepatitis B virus and the levels of TNF-αand TGF-β1.Besides,it is of high safety in use.