超声引导微通道经皮肾镜气压弹道碎石术对复杂性输尿管上段结石患者血清应激激素水平及炎性因子的影响

Effects of ultrasound-guided percutaneous nephrolithotomy combined with microchannel pneumatic lithotripsy on serum stress hormone levels and inflammatory factors in patients with complicated upper ureteral calculi

目的:分析超声引导微通道经皮肾镜气压弹道碎石术对复杂性输尿管上段结石患者血清应激激素水平及炎性因子的影响。方法:选取103例复杂性输尿管上段结石患者作为研究对象,按照随机数字表法分为观察组52例和对照组51例。对照组给予输尿管镜碎石术治疗,观察组给予超声引导微通道经皮肾镜气压弹道碎石术治疗,对比两组患者手术效果、应激激素水平和炎性因子水平。结果:观察组术后1个月结石清除率高于对照组,手术时间、术中出血量、术后住院时间均优于对照组(P<0.05);观察组促肾上腺皮质激素(ACTH)、皮质醇(COR)、去甲肾上腺素(NE)水平均低于对照组(P<0.05);观察组白细胞(WBC)计数、C反应蛋白(CRP)、白细胞介素-10(IL-10)水平均低于对照组(P<0.05)。结论:复杂性输尿管上段结石患者应用超声引导微通道经皮肾镜气压弹道碎石术效果确切,能够改善术后应激反应及炎症反应。

Objective:To analyze the effects of ultrasound-guided percutaneous nephrolithotomy on serum stress hormone levels and inflammatory factors in patients with complicated upper ureteral calculi.Methods:A total of 103 patients with complicated upper ureteral calculi were randomized into the observation group and control group.51 patients in the control group were treated with ureteroscope lithotripsy,while another 52 patients in the observation group were treated with ultrasound-guided percutaneous nephrolithotomy under pneumatic pressure.Then,the surgical effects,stress hormone level and inflammatory factors were compared between the two groups.Results:The calculus clearance rate 1 month after operation in the observation group was higher than that in control group,while the operation time,surgical blood loss and postoperative hospital stays were superior to those in control group(P<0.05);levels of ACTH,COR and NE in the observation group were lower than those in control group(P<0.05);WBC count,C-reactive protein(CRP)and interleukin-10(IL-10)levels in the observation group were lower than those in control group(P<0.05).Conclusion:Ultrasound-guided percutaneous nephrolithotomy with microchannel pneumatic lithotripsy is effective for patients with complicated upper ureteral calculi,which can improve postoperative stress response and inflammatory response.