不孕女性BMI与其卵泡浆内单精子注射助孕妊娠率的相关性分析

Correlation between BMI and pregnancy rate by intrafollicular sperm injection in infertile women

目的:分析不孕女性体质量指数(BMI)与其卵泡浆内单精子注射助孕妊娠率的相关性。方法:选取119例不孕女性,均行卵泡浆内单精子注射助孕,依据BMI将其分为两组,其中BMI≤23.9 kg/m^(2)的80例作为正常组,BMI>23.9 kg/m^(2)的39例作为超重组。比较两组Gn总量、Gn刺激时长、HCG日E_(2)、正常受精率、获卵数、全胚胎冷冻率、临床妊娠率、生化妊娠率、自然流产率、活产率、早产率。结果:正常组Gn刺激时长、Gn总量少于超重组,获卵数多于超重组,HCG日E_(2)高于超重组,全胚胎冷冻率高于对照组,以上差异均有统计学意义(P<0.05);两组临床妊娠率、生化妊娠率、自然流产率、活产率、早产率与超重组比较,均无统计学差异(P>0.05)。结论:不孕女性中体重正常者治疗期间的各项指标优于超重者,但不同BMI对于妊娠率、妊娠结局影响不明显。

Objective:To analyze the correlation between the body mass index(BMI)and the pregnancy rate of intrafollicular sperm injection in infertile women.Methods:A total of 119 infertile women underwent intracytoplasmic sperm injection to assist pregnancy were divided into two groups according to different BMI.Of whom,80 patients whose BMI≤23.9 kg/m^(2) were included in the normal group,and another 39 patients with BMI>23.9 kg/m^(2) were included in the overweight group.Total Gn,Gn stimulation duration,E_(2) at HCG d,normal fertilization rate,number of eggs retrieved,whole embryo freezing,clinical pregnancy rate,biochemical pregnancy rate,spontaneous abortion rate,live birth rate and preterm birth rate were compared between both groups.Results:The normal group had shorter duration of Gn stimulation,less total amount of Gn,higher number of eggs retrieved and higher E_(2) at HCG d than the overweight group,and the freezing rate of whole embryos was higher than that of the control group,which were all of statistical differences(P<0.05);and there was no statistical difference in clinical pregnancy rate,biochemical pregnancy rate,spontaneous abortion rate,live birth rate and preterm birth rate between the two groups(P>0.05).Conclusions:The indexes of infertile women with normal weight during treatment were better than those with overweight,but different BMI had no significant effect on pregnancy rate and pregnancy outcomes.