蔬菜摄入量与非酒精性脂肪肝病关系的前瞻性队列研究

RELATIONSHIPS BETWEEN DIETARY VEGETABLES CONSUMPTION AND NON-ALCOHOLIC FATTY LIVER DISEASE:A PROSPECTIVE COHORT STUDY

目的在中国成年人群中探讨蔬菜摄入量与非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)间的关联。方法研究数据来源于天津市慢性炎症与健康促进队列研究。参与者完成健康检查及食物频率问卷调查。采用协方差分析和Logistic回归分析描述参与者NAFLD发病情况及基线特征差异。运用COX比例风险回归模型分析蔬菜摄入量与NAFLD发病风险的关联。结果共15673名参与者纳入本研究,中位随访年为3.00年,其中3890名发生NAFLD,发病率为75.84/1000人年。调整潜在混杂因素后,与蔬菜摄入最低分位(Q1)相比Q2,Q3,Q4组发生NAFLD的HR值(95%CI)为0.92(0.84,1.01),0.84(0.76,0.93),0.88(0.79,0.98)(趋势性P<0.01)。结论蔬菜摄入量增加可显著降低NAFLD的发病风险,尤其是绿叶蔬菜,相关机制有待进一步研究。

Objective To explore the association between vegetables consumption and non-alcoholic fatty liver disease(NAFLD)in a Chinese adults cohort.Methods Data were from the Tianjin Chronic Inflammation and Health Promotion Cohort Study(TCLSIH).All participants completed physical examination and food frequency questionnaires.Analysis of covariance and logistic regression analysis were used to describe the differences in NAFLD prevalence and baseline characteristics.COX proportional risk regression models were used to analyse the association between vegetable intake and risk of NAFLD.Results A total of 15673 participants were included in this study,with a median follow-up period of 3.00 years.A total of 3890 participants developed NAFLD,with an incidence rate of 75.84/1000 person-years.After adjusting for potential confounders,the HRs(95%CI)for the occurrence of NAFLD in the Q2,Q3,and Q4 groups compared to the lowest quartile of vegetable intakes(Q1)were 0.92(0.84,1.01),0.84(0.76,0.93),and 0.88(0.79,0.98)(p<0.01 for trend).Conclusion Increased vegetables intake significantly reduces the risk of NAFLD,especially green leafy vegetables,and the associated mechanisms need to be further investigated.