ω-3多不饱和脂肪酸对妊娠期高血压疾病的免疫调节作用

Immunomodulatory effects of ω-3 polyunsaturated fatty acids on pregnancy-induced hypertension

目的探讨妊娠期补充ω-3多不饱和脂肪酸对妊娠期高血压疾病患者免疫功能的调节作用。方法纳入149例门诊治疗的妊娠期高血压患者,随机分为试验组和对照组。在给予保证睡眠、降压等相同基础治疗的同时,试验组每日给予二十六碳六烯酸(DHA)200 mg治疗4周。结果对照组与试验组试验前与试验4周后血尿指标血红蛋白、血小板、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、肌酐治疗前后差异无统计学意义(P>0.05),2组间24 h尿蛋白定量、尿酸、乳酸、乳酸脱氢酶及炎性指标IL-6、TNF-α、CRP治疗前差异无统计学意义(P>0.05),但随着孕周增大,数值逐渐上升,试验组上升趋势小于对照组,差异有统计学意义(P<0.05)。2组治疗过程中均有进展为重度子痫前期、出现胎盘早剥、胎儿宫内状况不佳或发生自发性流产、早产需住院治疗等情况发生,发生率差异无统计学意义(P>0.05)。结论ω-3多不饱和脂肪酸可以减缓妊娠期高血压患者尿蛋白、尿酸、乳酸、乳酸脱氢酶、IL-6、TNF-α、CRP增长,对其有一定免疫调节作用。

Objective To investigate the immunomodulatory effects ofω-3 polyunsaturated fatty acids on pregnancy-induced hypertension PIH).Methods A total of 149 patients with PIH who received outpatient treatment were enrolled I nthe study,who were randomly divided into experimental group and control group.In addition to basic treatment including sleep guarantee and reducing blood pressure,the 200mg DHA was given the patients in experimental group daily,however,those in control group were only given ordinary vitamin,with the treatment course of 4 weeks for both groups.Results There were no significant differences in hemoglobin,platelet,ALT,AST and creatinine before treatment and after 4-week treatment between the two groups(P>0.05).Before treatment there were no significant differences in 24h urinary protein quantification,uric acid,lactic acid,lactate dehydrogenase and inflammatory indexes IL-6,TNF-αand CRP between the two groups(P>0.05),however,with the increase of gestational age,the levels of above indexes were increased gradually,and the increasing trend in experimental group was significantly less than that in control group(P<0.05).During the treatment,both groups had partial progression to severe preeclampsia,placental abruption,poor fetal condition or spontaneous abortion,and premature delivery requiring hospitalization,but,there were no significant differences in the incidence rates of above complications between the two groups(P>0.05).Conclusion Theω-3 polyunsaturated fatty acids can slow down the increase of urinary protein,uric acid,lactic acid,lactate dehydrogenase,IL-6,TNF-αand CRP in patients with PIH,which has a certain immunomodulatory effect.