中国眼科干细胞再生医学领域现状及展望

Regenerative medicine in ophthalmology:current status and perspectives in China

再生医学是当代生命科学的前沿和新医学革命的核心领域.由于人类眼球结构与生理的独特性,眼组织再生是再生医学研究最活跃的领域之一,胚胎干细胞及诱导多能干细胞的临床试验均首先从眼科领域启幕,深刻影响和带动其他领域的临床转化.干细胞再生治疗正在革命性地改变、升级、更新眼科致盲性眼病的临床治疗,包括角膜疾病、白内障、青光眼、视网膜色素变性和年龄相关性黄斑变性等.本文对中国眼科干细胞再生医学的基础及临床研究现状进行总结,讨论当前面临的挑战,并展望了未来的发展方向.

Regenerative medicine is a hotspot in life science and plays a key role in the revolution of contemporary medicine.Because of the unique structure and physiology of the human eyes,the regeneration of eye tissues has become one of the most promising areas of life science.Remarkable studies of novel cell therapies derived from pluripotent stem cells and clinical trials were first performed in ocular diseases,which greatly improved translational medicine in other diseases.Stem cell-based therapies are now revolutionizing,upgrading,and renewing the treatment of many blinding diseases,including corneal disease,cataract,glaucoma,retinitis pigmentosa,and age-related macular degeneration.In this study,we outlined outstanding preclinical and clinical studies for regenerative medicine of ophthalmology in China and discussed the opportunities and challenges in the field.We hope that this review will stimulate new directions for regenerative medicine research.