巩膜胶原交联术防控近视研究的新进展

Advances in preventing myopia by scleral collagen crosslinking

近视患病率在全球范围内不断上升,防控近视极为重要.近视的发生发展与巩膜重塑、巩膜生物力学性能降低有关.巩膜胶原交联术是一种可以增强巩膜生物力学性能的方法,有望成为新型防控近视的有效手段.巩膜胶原交联术包括光辐照交联法(紫外光-核黄素巩膜胶原交联术、蓝光-核黄素巩膜胶原交联术)和生物交联剂交联法(京尼平、糖类、FARs和Tgases等)两类.本文就巩膜胶原交联术在防控近视方面的应用方案、有效性及安全性等内容进行综述.

The prevention of myopia is crucial due to its increasing prevalence globally. Myopia development is associated with scleral remodeling and reduced scleral biomechanical properties. Scleral collagen crosslinking is a new, effective approach to prevent myopia clinically, including photo-crosslinking by light irradiation(ultraviolet A and riboflavin scleral collagen crosslinking, and blue light and riboflavin scleral collagen crosslinking) and crosslinking by biological crosslinkers(genipin, carbohydrate, FARs, and Tgases).This article summarizes the relevant research on the application scheme, validity, and safety of scleral collagen crosslinking to prevent myopia.