改良型格拉斯哥评分在肝内胆管细胞癌根治性切除患者的预后判断中的价值

Modified Glasgow score in prediction of the prognosis of intrahepatic cholangiocarcinoma patients after radical surgical resection

目的探讨改良型格拉斯哥预后评分(mGPS)与根治性手术切除的肝内胆管细胞癌(ICC)患者预后的相关性。方法回顾性分析2011年1月—2020年12月宁波市医疗中心李惠利医院收治的126例行根治性手术切除的ICC患者临床资料,按照mGPS相关评分标准分别对患者进行评分,比较不同评分患者肿瘤临床病理特征及预后的差异。结果0分组(58例)术后1、3年生存率为85.8%、52.3%,1分组(41例)术后1、3年生存率为73.2%、23.0%,2分组(27例)术后1、3年生存率为73.3%、0,差异有统计学意义(均P<0.05)。单因素分析结果显示:年龄、mGPS、CA19-9、肿瘤直径、肿瘤分化程度是影响ICC预后的相关因素;多因素分析显示:年龄、肿瘤分化程度、肿瘤直径、mGPS是影响ICC预后的独立危险因素。结论mGPS是影响根治性手术切除的ICC患者预后的独立危险因素。

Objective To investigate the correlation between modified Glasgow prognostic score(mGPS)and prognosis of intrahepatic cholangiocarcinoma(ICC)patients after radical surgical resection.Methods The clinical data of 126 patients with intrahepatic cholangiocarcinoma undergoing radical surgical resection at Ningbo Medical Centre Lihuili Hospital from Jan 2011 to Dec 2020 were retrospectively analyzed.The patients were scored according to the mGPS-related scoring standards,and the differences in tumor clinicopathological characteristics and prognosis were compared between patients with different score levels.Results Firty-eight cases were included in group 0,41 cases in group 1,and 27 cases in group 2.The 1-and 3-year survival rates in group 0 were 85.8%and 52.3%,the 1-and 3-year survival rates in group 1 were 73.2%and 23%,and the 1-and 3-year survival rates in group 2 were 73.3%and 0.The difference was statistically significant(P<0.05).Univariate analysis showed that age,mGPS,CA19-9,tumor diameter,and tumor differentiation were related at the prognosis of ICC.Multivariate analysis showed that age,tumor differentiation,tumor diameter and mGPS were independent risk factors for the prognosis of ICC.Conclusion mGPS is an independent risk factor affecting the prognosis of ICC patients.