人类白细胞抗原-G在母-胎免疫界面的功能和作用机制

Mechanism and function of human leucocyte antigen G at the interface of maternal-fetal tolerance

人类白细胞抗原-G(human leucocyte antigen G, HLA-G)作为非经典的主要组织相容性复合物Ⅰ类分子, 在母-胎界面的绒毛膜外滋养层细胞上特异性表达。妊娠期间, 胎儿同种异源的绒毛膜外滋养细胞侵入子宫黏膜, 却免于母体来源的免疫细胞攻击, 其中HLA-G起到极其关键的作用。关于HLA-G在母-胎界面特殊调控方式的研究, 特别是与各类免疫细胞及膜表面受体作用的分子机制, 引起学者的广泛关注。本文将着重对HLA-G在母-胎界面的表达、调节及与相关免疫细胞作用机制进行综述。

Human leukocyte antigen G(HLA-G),one of the non-classical major histocompatibility complex class I molecules,is expressed uniquely on the extravillous trophoblast(EVT)cells at the maternal-fetal interface.Semi-allogeneic fetal EVT cells invade into the decidua during pregnancy without maternal immune cell attack,among which HLA-G plays an extremely important role.The special immune regulatory mechanisms of HLA-G at the interface of maternal-fetal tolerance,especially the possible molecular mechanisms interaction with immune cells and its membrane surface receptors,has been reentered into researchers'field.This review focuses on the expression,regulatory mechanisms and function related immune cells of HLA-G in the interface of maternal-fetal.