改良硼替佐米皮下注射法在减少注射部位色素沉着的应用研究

Application of improved bortezomib subcutaneous injection method in reducing skin pigmentation at injection site

目的:探讨改良硼替佐米皮下注射法减少注射部位皮肤色素沉着的价值。方法:选择2019年6月1日至2020年12月31日皮下注射硼替佐米的患者进行研究,以抛硬币法随机组,常规组293例采用传统标准皮下注射法,改良组293例采用改良硼替佐米皮下注射法,对两组皮下注射硼替佐米后24h、48h和72h注射部位色素沉着进行比较。结果:改良组硼替佐米皮下注射后24h、48h和72h注射部位色素沉着的发生率为分别为37.88%、38.91%和35.84%,与常规组的74.40%、83.96%和72.01%比较,差异均有统计学意义(P<0.05)。结论:改良硼替佐米皮下注射法可以减少注射部位色素沉着。

Objective:To explore the value of improved bortezomib subcutaneous injection method in reducing skin pigmentation at injection site.Methods:Patients who received subcutaneous injection of bortezomib from June 1,2019 to December 31,2020 were selected for the study.With coin tossing method,293 cases in the conventional group were treated with traditional standard subcutaneous injection method,and 293 cases in the improved group were treated with modified bortezomib subcutaneous injection method.The pigmentation of the injection site at 24h,48h and 72h was compared between the two groups.Results:The incidence of pigmentation at the injection site of bortezomib at 24h,48h and 72h in the improved group was 37.88%,38.91%and 35.84%respectively,compared with 74.40%,83.96%and 72.01%in the conventional group,the differences were statistically significant(P<0.05).Conclusion:The modified bortezomib subcutaneous injection method can reduce pigmentation of injection site.