激素治疗基础加服他克莫司或环磷酰胺对肾病综合征患者肾功能、炎症水平及免疫功能影响

The Effect of Hormone Therapy Combined withTacrolimus or Cyclophosphamide on Renal Function,Inflammation Level and Immune Function in Patients with Nephrotic Syndrome

目的:探讨他克莫司或环磷酰胺联合激素治疗对肾病综合征患者肾功能、炎症水平及免疫功能的影响。方法:选取2019年10月-2020年12月某院收治的90例肾病综合征患者进行研究,采用随机数字表法分为试验A组、试验B组和对照组各30例,对照组给予单纯激素治疗,试验A组给予激素联合他克莫司治疗,试验B组给予激素结合环磷酰胺治疗。比较3组患者的治疗总有效率、肾功能指标、炎症水平、免疫功能及不良反应。结果:试验A组、试验B组的治疗总有效率明显高于对照组(P<0.05);试验A组、试验B组的治疗总有效率比较无统计学差异(P>0.05)。试验A组、试验B组治疗后的肾功能、免疫功能、炎症因子水平优于治疗前和对照组(P<0.05);试验A组、试验B组治疗前后的肾功能、免疫功能、炎症因子水平比较均无统计学差异(P>0.05)。试验A组的不良反应发生率低于试验B组和对照组(P<0.05)。结论:激素联合他克莫司治疗肾病综合征患者的效果最为明显,能够有效改善患者肾功能及免疫功能,减轻机体炎症反应,且不良反应少,具有临床推广应用的价值。

Objective:To explore the effect of tacrolimus or cyclophosphamide combined with hormone therapy on renal function,inflammation level and immune function in patients with nephrotic syndrome.Methods:In this study,90 patients with nephrotic syndrome admitted to a hospital from October 2019 to December 2020 were selected for the study,and they were divided into test group A(n=30),test group B(n=30) and control group(n=30).The control group was given hormone therapy alone,the test group A was given hormone therapy combined with tacrolimus,and the test group B was given hormone therapy combined with cyclophosphamide.The total effective rate,renal function indexes,inflammation level,immune function and adverse reactions of the three groups of patients were compared.Results:The total effective rate of treatment in test group A and test group B was significantly higher than that in the control group(P0.05).The renal function,immune function,and inflammatory factors levels of test group A and test group B after treatment were better than those before treatment and those in the control group(P0.05).The incidence of adverse reactions in the test group A was significantly lower than that in the test group B and the control group(P<0.05).Conclusion:Hormone combined with tacrolimus has the most obvious effect in the treatment of patients with nephrotic syndrome,which can effectively improve the renal function and immune function of patients,and reduce the inflammatory response of the body,with few adverse reactions,and has the value of clinical promotion and application.