肠道益生菌联合蓝光照射治疗新生儿病理性黄疸的疗效及对患儿免疫功能的临床疗效观察

Efficacy of Intestinal Probiotics Combined with Blue Light Irradiation in the Treatment of Neonatal Pathological Jaundice and Its Effect on Immune Function of Patients

目的:探究新生儿病理性黄疸应用肠道益生菌、蓝光照射联合治疗的效果及其治疗前后免疫功能的变化。方法:将2019年1月-2020年12月某院108例新生儿病理性黄疸患儿纳入研究,按抽签法分为参照组和研究组各54例,参照组采用蓝光照射治疗,研究组在此基础上采用肠道益生菌治疗。以入院时(入院当天)、治疗后(治疗后10d)皮测总胆红素(TBiL)、间接胆红素(IBiL)水平、血清CD4^(+)、CD8^(+)表达水平变化及治疗期间皮疹、腹泻、脱水、青铜症发生率完成对胆红素指标、免疫功能指标、不良反应的评价。结果:治疗后,研究组TBiL、IBiL水平低于入院时,且低于参照组,差异显著(P<0.05);治疗后,研究组CD4^(+)高于入院时,CD8^(+)低于入院时,且改变幅度大于参照组,差异显著(P<0.05);研究组不良反应发生率为5.56%,参照组为9.26%,对比无显著差异(P>0.05)。结论:肠道益生菌、蓝光照射联合治疗能够显著降低患儿的胆红素水平,改善其免疫功能,且不会提升不良反应发生率,应用于新生儿病理性黄疸中安全、有效。

Objective:To discuss the effects of intestinal probiotics combined with blue light irradiation in the treatment of neonatal pathological jaundice and changes of immune function before and after treatment.Methods:108 newborns in a hospital from January 2019 to December 2020 were selected and randomly divided into reference group(n=54,blue light therapy) and study group(n=54,blue light therapy and intestinal probiotics).The evaluation of bilirubin indexes,immune function indexes,and adverse reactions was completed according to the changes of total bilirubin,indirect bilirubin,and serum CD4^(+) and CD8^(+) expression levels on admission and after treatment(10 d after treatment) and the incidence of complications such as rash,diarrhea,dehydration,and bronze disease during the treatment.Results:TBiL and IBiL in the study group after treatment were lower than those on admission and lower than those in the reference group,with significant difference(P0.05).Conclusion:Intestinal probiotics combined with blue light therapy can significantly reduce the level of bilirubin in the children,improve their immune function,and will not increase the incidence of adverse reactions,which is safe and effective in neonatal pathological jaundice.