埃索美拉唑与奥美拉唑治疗胃溃疡的疗效研究

Therapeutic Effect of Esomeprazole and Omeprazole in the Treatment of Gastric Ulcer

目的:分析胃溃疡疾病特点,对比评价埃索美拉唑、奥美拉唑治疗的预后情况,为胃溃疡疾病药物治疗提供参考。方法:研究对象均为消化内科患者,选取时间段2020年1月-2020年12月,从中抽取符合此次研究的胃溃疡患者160例为研究对象,采用随机法分为观察组和对照组各80例,均使用四联疗法治疗,基础用药为阿莫西林+克拉霉素+胶体果胶铋+抑酸剂,对照组采用奥美拉唑,观察组采用埃索美拉唑,对比两组胃溃疡患者经不同药物方案治疗后情况,即疗效、症状、胃黏膜结构与功能评分变化、各项血清指标变化。结果:观察组治疗有效率明显高于对照组(P<0.05);观察组治疗后腹痛、腹胀、烧灼感、反酸、嗳气等症状评分下降,且较对照组患者更低(P<0.05);观察组中性粒细胞浸润程度、腺体密度、黏膜厚度减少等评分明显低于对照组(P<0.05);观察组治疗后TNF-α、IL-8、MMP-3、MMP-9、TIMP-1水平明显低于对照组(P<0.05)。结论:采用埃索美拉唑治疗,能有效改善胃溃疡患者的临床症状,促进胃黏膜结构与功能的恢复,降低炎性因子及MMs和TIMP-1水平,促进溃疡面愈合,值得优先选择。

Objective:To analyze the characteristics of gastric ulcer diseases,compare the prognosis of esomeprazole and omeprazole treatment,and provide a reference for the drug treatment of gastric ulcer diseases.Methods:A total of 160 cases of patients with gastric ulcer in accordance with this study treated in a hospital from January 2020 to December 2020 were selected as the study subjects and random divided into the two groups.The two groups were treated with the quadruple therapy,and the basic medication was amoxicillin+clarithromycin+colloidal bismuth pectin+antacids.Then the control group was given omeprazole treatment and the observation group was given esomeprazole treatment.The conditions including curative effect,symptoms,gastric mucosal structure,functional scores and serum indicators of the two groups of gastric ulcer patients after treatment with different drug regimens were compared.Results:The effective rate of treatment was significantly higher in the observation group than in the control group(P<0.05).The scores of symptoms such as abdominal pain,bloating,burning sensation,acid reflux,belching and other symptoms after treatment in the observation group were decreased,which was lower than the control group(P<0.05).The scores of degree of neutrophil infiltration,gland density,decreased mucosa thickness in the observation group were significantly lower than those in the control group(P<0.05).The TNF-α,IL-8,MMP-9,and TIMP-1 levels in the observation group after treatment were significantly lower than those in the control group(P<0.05).Conclusion:The application of esomeprazole in the treatment of gastric ulcer can effectively improve the clinical symptoms of patients,promote the recovery of gastric mucosa structure and function,reduce inflammatory factors and levels of MMS and TIMP-1,and promote ulcer surface healing,which is worth the priority of choice.