超级微波消解-电感耦合等离子体质谱法测定化妆品中40种元素

Determination of 40 Elements in Cosmetics Based on Super Microwave Digestion Inductively Coupled Plasma Mass Spectrometry

建立同时测定化妆品中40种元素的超级微波消解-电感耦合等离子体质谱法。样品经超级微波消解,采用电感耦合等离子体质谱法测定,在线内标校正,外标法定量。方法学验证,对146批样品进行了测定和检测结果分析评价。结果表明,该方法的线性关系良好,相关系数(r)为0.9969~1.0000,检出限为0.1~10μg/kg,加标回收率为86.8%~113.6%,精密度为1.1%~5.7%,方法简便、快速、准确、适用化妆品中元素的测定。146批实际样品测定,汞、铅、砷、镉4种元素以及16种稀土元素安全状况良好,镍(Ni)、铬(Cr)、钡(Ba)三种禁用组分及其盐存在一定的的安全风险,2批样品可能存在原料重金属污染,建议开展镍(Ni)、铬(Cr)、钡(Ba)及其盐的限度研究和加强对化妆品原料中元素的分析与风险评估。

A super microwave digestion inductively coupled plasma mass spectrometry method for the simultaneous determination of 40 elements in cosmetics was established.The samples were digested by super microwave and determined by ICP-MS using on-line internal standard correction and external standard method for quantification.After validation of the methodology, 146 batches of samples were determined and the results were analyzed.Results showed that all the elements had a good linear relationship, with the correlation coefficients was 0.9969~1.0000,the minimum detection limits was 0.1~10 μg/kg, the recovery rates was 86.8%~113.6%, and the precision was 1.1%~5.7%.The method was simple, rapid, accurate and can be used to the determination of elements in cosmetics.In 146 batches of actual samples, four elements including mercury, lead, arsenic, cadmium and 16 rare earth elements are in good safety condition, three banned components including Nickel(Ni),Chromium(Cr),barium(Ba)and their salts had certain safety risks, and two batches of samples may be contaminated by heavy metals.It was suggested to study the limits of nickel(Ni),chromium(Cr),barium(Ba)and their salts, and strengthen the analysis and risk assessment of elements in cosmetic raw materials.