药物性肝损伤的研究进展

Research progress of drug-induced liver injury

药物性肝损伤(DILI)是指继发于药物使用后,由药物和/或药物代谢物引起的肝脏损伤,常由各类处方药和非处方药、草药、膳食添加剂适量或者过量摄入引起。DILI的发病率逐年升高,也是导致急性肝衰竭的主要原因之一,而一旦进展为急性肝衰竭,只能进行肝移植治疗。本文主要对DILI的流行病学、发病机制、常见药物、生物标志物进行综述。

Drug-induced liver injury(DILI) refers to the liver injury caused by drugs and/or drug metabolites secondary to drug use,which is often caused by the appropriate or excessive intake of various prescription and over-thecounter drugs,herbs and dietary additives.The incidence rate of DILI is increasing year by year,which is also one of the main causes of acute liver failure.Once it progresses to acute liver failure,it can only be treated by liver transplantation.This article mainly reviews the epidemiology,pathogenesis,common drugs and biomarkers of DILI.