中医药治疗肉芽肿性乳腺炎疗效的Meta分析

Meta-analysis of Traditional Chinese Medicine in the Treatment of Granulomatous Mastitis

目的:系统评价中医药治疗肉芽肿性乳腺炎(GLM)的临床疗效及安全性。方法:检索建库至今发表于CNKI、VIP、CBM及PubMed数据库中关于中医药治疗GLM的期刊文献,文献类型限于临床随机对照试验(RCT)。应用Meta分析方法的纳入、排除标准进行严格筛选,对纳入文献进行定量综合分析。结果:共纳入文献12篇,包括864例GLM患者,其中治疗组443例,对照组421例。Meta分析显示,中医药治疗GLM的总有效率高于西医治疗[OR=3.11,95%CI(1.92,5.03),Z=4.63,P<0.00001],同样在乳房优良率上比西医治疗有优势(P<0.05),而毒副反应、复发率两组间无统计学差异(P>0.05)。结论:中医药治疗GLM有较大的优势;现阶段研究文献可能欠严谨,需要更多高质量的临床随机对照文献。

To evaluate the clinical effect and safety of Traditional Chinese medicine(TCM)therapy for granulomatous mastitis(GLM).Methods The CNKI,WanFang,VIP and PubMed databases were searched by computer to find randomized controlled trials(RCTs)on the treatment of GLM with traditional Chinese and western medicine.They were strictly screened according to the inclusion and exclusion criteria of Meta analysis.A comprehensive and quantitative analysis of the literature was made.Results There are 864 cases of granulomatous mastitis in a1112 documents,of which 443 cases in treatment group and 421 cases in control group.The Meta-analysis showed that the total effective rate of TCM treatment group Was significantly higher than that of the Western medicine control group[OR=3.11,95%CI(1.92,5.03),Z=4.63,P<0.00001].At the same time,TCM treatment is more effective than Western medicine treatment in the rate of breast excellence(P<0.05).And yet there was no significant difference in toxicity and recurrence rate between the two groups(P>0.05).Conclusion TCM for GLM has a few higher advantages.And the current research literature may be not strict.We need more high quality RCTs research papers.