瓜参汤治疗气阴两虚型慢性疲劳综合征临床疗效观察

Clinical Effect of Guashen Decoction on Chr onic Fatigue Syndrome of Deficiency of Qi and Yin

目的:观察瓜参汤治疗气阴两虚型慢性疲劳综合征的临床疗效。方法:选取2021年1月1日—2021年11月30日亳州市华佗中医院门诊治疗的86例气阴两虚型慢性疲劳综合征患者作为研究对象,按照随机原则将其分为治疗组和对照组,对照组予以生脉饮口服结合健康生活方式等综合治疗,治疗组在生活方式干预的基础上予以瓜参汤治疗。分析两组治疗前后的疲劳量表-14、中医证候症状积分量表、白细胞介素-6、肿瘤坏死因子-α、免疫球蛋白A、免疫球蛋白M、免疫球蛋白G,观察并对比两组临床疗效。结果:治疗组总有效率为97.5%(40/41),显著优于对照组的82.9%(34/41),P<0.05。治疗后治疗组的疲劳量表-14、中医证候症状评分、白细胞介素-6、肿瘤坏死因子-α均低于治疗前且低于治疗后对照组,P<0.05。治疗后治疗组免疫球蛋白A、免疫球蛋白M、免疫球蛋白G测定值均高于治疗前且高于治疗后对照组,P<0.05。结论:瓜参汤治疗气阴两虚型慢性疲劳综合征临床疗效显著,可有效改善患者疲劳诸相关症状,并可有效调节白细胞介素-6、肿瘤坏死因子-α、免疫球蛋白A、免疫球蛋白M、免疫球蛋白G等炎症因子、免疫水平,值得推广应用。

Objective:To observe the clinical efficacy of Guashen Decoction in the treatment of chronic fatigue syndrome of Qi and Yin deficiency type.Methods:Selected 86 patients with chronic fatigue syndrome of Qi-yin deficiency type from January 1,2021 to November 30,2021 in Bozhou Huatuo Hospital of Traditional Chinese Medicine as the research objects,and divided them into treatment groups according to the principle of randomization and the control group,the control group was given comprehensive treatment such as oral Shengmai Decoction combined with healthy lifestyle,and the treatment group was given Guashen decoction on the basis of lifestyle intervention.The fatigue scale-14,TCM syndrome symptom score scale,interleukin-6,tumor necrosis factor-α,immunoglobulin A,immunoglobulin M,and immunoglobulin G of the two groups before and after treatment were analyzed,and the observation and comparison were made.The clinical efficacy of the two groups.Results:The total effective rate of the treatment group was 97.5%(40/41),which was significantly better than that of the control group,82.9%(34/41)(P<0.05).After treatment,the fatigue scale-14,TCM syndrome symptom score,interleukin-6 and tumor necrosis factor-αin the treatment group were all lower than those before treatment and lower than those in the control group after treatment(P<0.05).After treatment,the measured values of immunoglobulin A,immunoglobulin M and immunoglobulin G in the treatment group were higher than those before treatment and higher than those in the control group after treatment(P<0.05).Conclusion:Guashen Decoction has significant clinical efficacy in the treatment of chronic fatigue syndrome of Qi and Yin deficiency,can effectively improve various symptoms of fatigue in patients,and can effectively regulate interleukin-6,tumor necrosis factor-α,immunoglobulin A,immune Inflammatory factors and immune levels such as globulin M and immunoglobulin G are worthy of popularization and application.