男性与女性糖尿病患者动脉粥样硬化的危险因素分析

Risk Factors of Atherosclerosis in Male and Female Diabetic Patients

目的分析男性与女性糖尿病患者动脉粥样硬化的危险因素,为临床防治动脉粥样硬化提供参考依据。方法选取山东第一医科大学附属成武医院2020年6月—2021年6月收治的120例糖尿病患者,所有患者均行SeimensS2000彩色超声诊断仪检测颈动脉内中膜厚度,检测值≤1.0 mm提示颈动脉壁正常,纳入正常组(n=67),检测值>1.0 mm提示颈动脉壁增厚,纳入硬化组(n=53)。对比两组患者男性与女性相关资料的差异性,并运用Logistic分析法分析男性与女性患者动脉粥样硬化的危险因素。结果多因素Logistic分析结果显示,年龄、有吸烟史、有饮酒史、高血压、脑梗死、冠心病、空腹血糖、餐后2 h血糖、糖化血红蛋白、收缩压、总胆固醇、三酰甘油、低密度脂蛋白、尿酸、C反应蛋白均是男性患者动脉粥样硬化的危险因素(OR=2.134、3.012、3.255、2.112、1.086、2.134、3.153、2.018、3.022、2.068、3.455、2.255、3.843、3.022、3.155);年龄、高血压、脑梗死、冠心病、糖尿病周围神经病变、糖尿病足、空腹血糖、餐后2 h血糖、糖化血红蛋白、收缩压、总胆固醇、三酰甘油、低密度脂蛋白、尿酸、C反应蛋白均是女性患者动脉粥样硬化的危险因素(OR=2.122、2.145、3.012、1.563、2.343、2.155、3.144、2.356、3.144、2.682、3.156、3.144、2.685、2.133、3.122)。结论男性与女性糖尿病患者动脉粥样硬化的危险因素存在一定的差异性,临床应针对不同性别患者实施不同的干预措施,以降低动脉粥样硬化发生风险。

Objective To analyze the risk factors of atherosclerosis in male and female diabetic patients,and to pro⁃vide reference for clinical prevention and treatment of atherosclerosis.Methods A total of 120 diabetic patients ad⁃mitted to Chengwu Hospital Affiliated to Shandong First Medical University from June 2020 to June 2021 were se⁃lected.Seimens S2000 color ultrasound diagnostic instrument was used to detect carotid intima-media thickness in all patients.The normal group(n=67)was included,and the detected value>1.0 mm indicated thickening of the ca⁃rotid artery wall,and the sclerosis group(n=53)was included.The differences of related data between males and fe⁃males in the two groups were compared,and the risk factors of atherosclerosis in males and females were analyzed by Logistic analysis.Results The results of multivariate Logistic analysis showed that age,smoking history,drinking his⁃tory,hypertension,cerebral infarction,coronary heart disease,fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,systolic blood pressure,total cholesterol,triglyceride,low density lipid protein,uric acid,and C-reactive protein are all risk factors for atherosclerosis in male patients(OR=2.134,3.012,3.255,2.112,1.086,2.134,3.153,2.018,3.022,2.068,3.455,2.255,3.843,3.022,3.155).Age,hypertension,cerebral infarction,coro⁃nary heart disease,diabetic peripheral neuropathy,diabetic foot,fasting blood glucose,2 h postprandial blood glu⁃cose,glycosylated hemoglobin,systolic blood pressure,total cholesterol,triglyceride,low-density lipoprotein,uric acid,C-reactive protein were risk factors for atherosclerosis in female patients(OR=2.122,2.145,3.012,1.563,2.343,2.155,3.144,2.356,3.144,2.682,3.156,3.144,2.685,2.133,3.122).Conclusion There are certain differ⁃ences in the risk factors of atherosclerosis in male and female diabetic patients.Different intervention measures should be implemented for different gender patients in order to reduce the risk of atherosclerosis.