地屈孕酮治疗反复性早期流产的临床效果研究

Clinical Effect of Dydrogesterone in the Treatment of Recurrent Early Abortion

目的探讨地屈孕酮在反复性早期流产患者中的临床治疗效果。方法抽取沂南县妇幼保健院在2019年4月-2021年4月收治的反复性早期流产患者进行分组,按入院时间分为对比组和研究组,每组30例,共计患者60例。对比组患者采用黄体酮进行治疗,研究组患者采用地屈孕酮治疗。对比两组反复性早期流产患者的血清孕酮水平、雌二醇(17β-estradiol,E2)以及人绒毛膜促进腺激素(Human chorionic gonadotro⁃pin,HCG)水平、保胎成功率、不良反应发生率。结果经过治疗,研究组患者和对比组患者的流产情况都有所改善。在血清孕酮、E2以及HCG水平的对比中,两组患者治疗前差异无统计学意义(P>0.05)。治疗后研究组血清孕酮、E2以及HCG水平高于对比组,差异有统计学意义(P<0.05);研究组保胎成功率83.33%,较对比组的60.00%成功率更高,差异有统计学意义(χ^(2)=4.022,P=0.045);研究组2例出现不良反应,对比组8例,差异有统计学意义(P<0.05)。结论在治疗反复性早期流产时,地屈孕酮的临床效果更好,不仅能明显地改善患者孕酮水平,还能提高胎儿的存活率和降低患者不良反应发生率。

Objective To investigate the clinical effect of dydrogesterone in patients with recurrent early abortion.Methods The patients with recurrent early miscarriage admitted to Yinan County Maternal and Child Health Hospital from April 2019 to April 2021 were selected and divided into control group and study group according to the admis⁃sion time,with 30 patients in each group,totaling 60 patients.The patients in the control group were treated with pro⁃gesterone,and the patients in the study group were treated with dydrogesterone.The serum progesterone levels,17β-estradiol(E2)and HCG levels,the success rate of miscarriage protection and the incidence of adverse reactions were compared between the two groups of patients with recurrent early abortion.Results After treatment,abortion im⁃proved in both the study group and the control group.There was no statistically significant difference in serum pro⁃gesterone,E2 and human chorionic gonadotropin(HCG)levels between two groups before treatment(P>0.05).Af⁃ter treatment,the levels of serum progesterone,E_(2) and HCG in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05);the success rate of fetal preservation in the study group was 83.33%,which was higher than that in the control group(60.00%),and the difference was statistically sig⁃nificant(χ^(2)=4.022,P=0.045);adverse reactions occurred in 2 patients in the study group and 8 patients in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of recurrent early miscar⁃riage,dydrogesterone has a better clinical effect,not only can significantly improve the progesterone level of patients,but also improve the survival rate of the fetus and reduce the incidence of adverse reactions in patients.