载脂蛋白E基因多态性与动脉粥样硬化性脑梗死相关性的研究

Correlation between Apolipoprotein E Gene Polymorphism and Athero⁃sclerotic Cerebral Infarction

目的 研究载脂蛋白E基因多态性与动脉粥样硬化性脑梗死的相关性。方法 选取2017年3月-2018年9月期间潮州市中心医院收治的191例动脉粥样硬化性脑梗死患者和同期本院收治的137例非脉粥样硬化性脑梗死患者为研究对象,将非脉粥样硬化性脑梗死患者设为对照组,动脉粥样硬化性脑梗死患者设为研究组。对两组研究对象进行三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白E(ApoE)基因的测定并对比结果。结果 研究组患者的TC水平(5.15±0.71)mmol/L、ApoE水平(44.37±6.43)mg/100 mL、TG水平(1.67±0.62)mmol/L、HDL-C水平(1.49±0.82)mmol/L均低于对照组,差异有统计学意义(P<0.05)。研究组患者的ApoE ε3等位基因频率为53.93%,高于对照组的42.34%;ApoE ε2、ε4等位基因频率分别为2.62%和1.57%,均低于对照组的7.30%和8.76%,差异有统计学意义(χ^(2)=4.289、4.006、9.446,P<0.05)。Pearson分析结果显示,ApoE等位基因ε2、ε4与动脉粥样硬化性脑梗死患者血清TC、TG、HDL-C及ApoE水平呈正相关(P<0.05);ApoE等位基因ε3与动脉粥样硬化性脑梗死患者血清TC、TG、HDL-C及ApoE水平呈负相关(P<0.05)。结论 载脂蛋白E基因多态性与动脉粥样硬化性脑梗死相关,但可能并不是唯一有关因素,同样应该加强对TG、TC、HDL-C及LDL-C的关注,从而避免梗死的发生,减轻其家庭及社会负担。

Objective To study the correlation between apolipoprotein E gene polymorphism and atherosclerotic cerebral infarction.Methods A total of 191 patients with atherosclerotic cerebral infarction admitted to the Chaozhou Central Hospital from March 2017 to September 2018 and 137 non-atherosclerotic cerebral infarction patients admitted to the hospital during the same period were selected as the research objects.Patients with non-atherosclerotic cerebral infarction were set as the control group,and patients with atherosclerotic cerebral infarction were set as the study group.Triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),and apolipoprotein E(ApoE) genes were measured in the two groups of subjects and compared the results.Results The TC level(5.15±0.71) mmol/L,ApoE level(44.37±6.43) mg/100 mL,TG level(1.67±0.62) mmol/L,HDLClevel(1.49±0.82) mmol/L of study group patients were lower than the control group,the difference was statistically significant(P<0.05).The ApoE ε3 allele frequency of the patients in the study group was 53.93%,which was higher than 42.34% of the control group;the ApoE ε2 and ε4 allele frequencies were 2.62% and 1.57%,respectively,which were lower than 7.30% and 8.76% of the control group,and the difference was statistically significant(χ^(2)=4.289,4.006,9.446,P<0.05).Pearson analysis showed that ApoE alleles ε2 and ε4 were positively correlated with serum TC,TG,HDL-C and ApoE levels in patients with atherosclerotic cerebral infarction(P<0.05).ApoE allele ε3 was negatively correlated with serum TC,TG,HDL-C and ApoE levels in patients with atherosclerotic cerebral infarction(P<0.05).Conclusion Apolipoprotein E gene polymorphism is associated with atherosclerotic cerebral infarction,but it may not be the only related factor.Similarly,attention should be paid to TG,TC,HDL-C and LDL-C,so as to avoid the occurrence of infarction and reduce the burden on the family and society.