吸入用乙酰半胱氨酸溶液辅助吸入用丙酸倍氯米松、硫酸特布他林治疗小儿支气管肺炎的效果探讨

Effect of Acetylcysteine Solution for Inhalation Assisted by Inhalation of Beclomethasone Propionate and Terbutaline Sulfate in the Treatment of Children with Bronchopneumonia

目的研究吸入用乙酰半胱氨酸溶液辅助吸入用丙酸倍氯米松、硫酸特布他林治疗小儿支气管肺炎的效果。方法选取2019年7月-2021年6月盱眙县人民医院治疗小儿支气管肺炎患儿64例为研究对象,随机分为对照组和研究组。对照组(n=34)实施吸入用丙酸倍氯米松、硫酸特布他林治疗;研究组(n=30)实施三联用药,即通过吸入用乙酰半胱氨酸溶液辅助吸入用丙酸倍氯米松、硫酸特布他林治疗。比较两组患儿治疗总有效率、体征消失的时间、住院时间、临床体征及出现的不良反应。结果研究组总有效率为96.67%,明显高于对照组,差异有统计学意义(χ^(2)=7.615,P<0.05);研究组肺部啰音消失时间为(5.18±0.48)d、退热时间(2.56±0.23)d、气促消失时间(5.95±1.03)d和住院时间(6.33±0.78)d短于对照组,差异有统计学意义(t=21.157、18.353、4.237、14.900,P<0.05);研究组患儿不良反应发生率低于对照组,差异有统计学意义(χ^(2)=4.836,P<0.05)。结论通过采取吸入用乙酰半胱氨酸溶液辅助吸入用丙酸倍氯米松、硫酸特布他林的方法治疗小儿支气管肺炎,可以达到很好的效果,缩短住院时间,且无明显的不良反应。

Objective To study the effect of inhalation of acetylcysteine solution assisted by inhalation of beclometha⁃sone propionate and terbutaline sulfate in the treatment of children with bronchopneumonia.Methods A total of 64 children with bronchopneumonia in Xuyi County People's Hospital from July 2019 to June 2021 were selected as the study objects,and they were randomly divided into the control group and the study group.Control group(n=34)were treated with inhalation of beclomethasone propionate and terbutaline sulfate;study group(n=30)used triple-drug therapy,that was,the inhalation of acetylcysteine solution assisted by inhalation of beclomethasone propionate and terbutaline sulfate to treat children with bronchial pneumonia.The total effective rate of treatment,the disappearance time of signs,hospitalization time,clinical signs and adverse reactions of the two groups of children were compared.Results The total effective rate of the study group was 96.67%,which was significantly higher than that of the control group,the difference was statistically significant(χ^(2)=7.615,P<0.05).The disappearance time of pulmonary rales in the study group was(5.18±0.48)d,the time for fever reduction(2.56±0.23)d,the time for disappearance of shortness of breath(5.95±1.03)d,and the hospitalization time(6.33±0.78)d shorter than that of the control group,the differ⁃ence was statistically significant(t=21.157,18.353,4.237,14.900,P<0.05).The probability of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(χ^(2)=4.836,P<0.05).Conclusion The inhalation of acetylcysteine solution assisted by inhalation of beclomethasone propionate and terbutaline sulfate in the treatment of children with bronchopneumonia can achieve good results and shorten the hos⁃pital stay,without obvious adverse reactions.