盐酸氨溴索联合莫西沙星对老年慢性支气管炎急性发作的疗效探讨

Effects of Ambroxol Hydrochloride Combined with Moxifloxacin on Acute Attack of Chronic Bronchitis in the Elderly

目的:探讨盐酸氨溴索联合莫西沙星对老年慢性支气管炎(CB)急性发作的疗效。方法:选取2018年2月~2019年8月本院收治的老年CB急性发作患者96例作为研究对象,采用随机数字表法分为对照组和观察组,每组48例。两组患者在解痉镇咳、祛痰平喘等常规治疗基础上,对照组给予莫西沙星治疗,观察组给予盐酸氨溴索联合莫西沙星治疗。对比两组患者症状消除时间、治疗前后肺功能和血清炎症因子水平变化情况、临床疗效及不良反应发生情况。结果:观察组肺部啰音、咳嗽咳痰、发热及呼吸困难症状消除时间短于对照组(P<0.05);治疗后,两组患者第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及FEV1/FVC高于治疗前(P<0.05),且观察组高于对照组(P<0.05);治疗后,两组患者白介素-6(IL-6)、白介素-8(IL-8)及超敏C反应蛋白(hs-CRP)水平低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组患者不良反应发生率比较无统计学差异(P>0.05)。结论:盐酸氨溴索联合莫西沙星治疗可缩短老年CB急性发作症状消除时间,提高肺功能,降低血清炎性因子水平,且安全可靠。

Objective:To explore the effects of ambroxol hydrochloride combined with moxifloxacin on acute attack of chronic bronchitis(CB)in the elderly.Methods:A total of 96 elderly patients with acute CB attack from February 2018 to August 2019 were selected as the research subjects,and they were randomly divided into control group and observation group by random number table method,48 patients in each group.Both groups were given routine treatment such as antispasmodic and antitussive,expectorant and antiasthmatic,and the control group was given moxifl oxacin,while the observation group was given ambroxol hydrochloride combined with moxifloxacin.The time of symptom elimination,changes of lung function and serum infl ammatory factor levels,clinical effi cacy and incidence of adverse reactions were compared between the two groups before and after treatment.Results:The elimination time of lung rale,cough and expectoration,fever and dyspnea in the observation group was signifi cantly shorter than that in the control group(P<0.05).After treatment,forced expiratory volume in the fi rst second(FEV1),forced vital capacity(FVC)and FEV1/FVC of the two groups were signifi cantly higher than those before treatment(P<0.05),and the observation group were higher than those of the control group(P<0.05).The levels of interleukin-6(IL6),interleukin-8(IL-8)and hypersensitive C reactive protein(hs-CRP)in the two groups were signifi cantly lower than those before treatment(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).There was no statistical diff erence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ambroxol hydrochloride combined with moxifl oxacin can shorten the time for the elimination of acute symptoms of CB in the elderly,improve lung function,and reduce the level of serum infl ammatory factors,which is safe and reliable.