α-Klotho保护移植肾功能的研究进展

α-Klotho in renal allograft function protection

α-Klotho主要表达于近端肾小管上皮细胞,具有调节钙磷和维生素D代谢、抗炎、抗氧化、抗凋亡等多种生物学作用,特别是在改善肾脏缺血再灌注损伤和纤维化方面扮演着重要角色。近年来,α-Klotho在肾移植领域越来越受到关注,其血液和组织水平均被认为与移植肾功能直接相关,核因子κB和Wnt/β-Catenin等信号通路可能均有参与,一些干预性措施也应运而生。本文将对α-Klotho在肾移植领域中的研究进展进行全面综述,以期为改善移植肾功能并最终改善移植肾受者的预后提供新思路。

α-Klotho is mainly expressed in proximal renal tubular epithelial cells, which has many biological functions, such as regulating calcium, phosphorus and vitamin D metabolism, anti-inflammatory, antioxidant and anti apoptotic. Especially in improving renal ischemia-reperfusion injury and fibrosis, it plays an important role. Recent years, it has attracted more and more attention in the field of renal transplantation. Its blood and tissue levels are considered to be directly related tofunction of transplanted kidney, NF-κB and Wnt/β-Catenin signaling pathways may be involved, and some intervention measures also gradually emerge. In this paper, we will discuss research progress of α-Klotho in the field of renal transplantation, in order to provide new intervention targets for improving allograft function and prognosis of renal transplant recipient.