益髓方对环磷酰胺致血小板计数减少模型小鼠的影响

Effect of Yisui Recipe on Cyclophosphamide-induced Thrombocytopenia in Model Mice

目的 观察医院制剂益髓方对环磷酰胺致血小板计数减少模型小鼠的影响。方法 将72只健康KM小鼠随机分为正常对照组、模型对照组、益血生胶囊对照组与益髓方大、中、小剂量组。分别予腹腔注射环磷酰胺,制备血小板减少症小鼠模型,观察益髓方大、中、小剂量对模型小鼠外周血血小板计数的影响。结果 与模型对照组比较,益髓方大、中、小剂量组小鼠外周血血小板计数均明显提升(P<0.05)。与模型对照组比较,益血生胶囊对照组小鼠外周血白细胞计数明显升高(P<0.05),益髓方各剂量组白细胞计数变化不明显。与正常对照组比较,用药各组小鼠骨髓增殖程度比较,差异无统计学意义(P>0.05)。结论 益髓方大、中、小剂量组对环磷酰胺致血小板计数减少有治疗作用,且可能有降低化疗致骨髓损伤作用,益血生胶囊对环磷酰胺致白细胞计数减少有治疗作用,均值得进一步深入研究并推广应用。

Objective To observe the effect of hospital preparation Yisui Recipe on cyclophosphamide-induced thrombocytopenia in model mice.Methods 72 healthy KM mice were randomly divided into 6 groups:normal control,model control,Yixuesheng Capsule control and Yisui Recipe large,medium and low dose groups.Cyclophosphamide was injected intraperitoneally to prepare a mouse model of thrombocytopenia,and the effect of large,medium and small doses of Yisui Recipe on the peripheral blood platelet count of the model mice was observed.Results Compared with the model control group,the peripheral blood platelet counts of the mice in the large,medium and low dose groups of Yisui Recipe increased significantly(P0.05).Conclusion The large,medium and small dose groups of Yisui Recipe have a therapeutic effect on cyclophosphamide-induced thrombocytopenia,and may reduce bone marrow damage caused by chemotherapy.Yixuesheng Capsule has a therapeutic effect on cyclophosphamide-induced leukopenia,and they are both worthy of further in-depth research and popularization and application.