食品功能因子稳态化靶向递送与精准营养

Stabilization and Targeted Delivery of Food Functional Factor and Precision Nutrition

膳食结构与营养平衡对于人体健康具有重要作用,不合理的膳食与慢性疾病高发密切相关。精准营养旨在针对个体背景特征进行安全、高效的营养干预,改善膳食失衡,维持人体健康并有效预防和控制疾病。食品中的功能因子能通过激活酶的活性或其它途径调节人体机能,是实现精准营养的重要物质基础,也是营养调控的重要手段。针对功能因子溶解性不好、稳定性差和生物利用度低等问题,建立稳态化靶向递送体系,有助于改善功能因子的稳定性并提高其生物利用度,实现体内的靶向作用位点控制释放,为精准营养提供营养干预途径和方法。本文概述精准营养与生命健康的重要联系,食品功能因子靶向递送对实现精准营养的促进作用,以及面临的瓶颈问题;论述食品功能因子稳态化靶向递送与控释的现状,以及与精准营养的内在联系和重要作用。详细介绍活性多肽、不饱和脂肪酸、多酚及类胡萝卜素等稳态化靶向递送对炎性肠病、癌症、酒精性脂肪肝、动脉粥样硬化和肥胖等疾病的营养干预作用。对国内精准营养产业发展动态、存在的机遇与挑战进行总结和展望,旨在为食品功能因子稳态化靶向递送与产业化应用提供参考。

Dietary structure and nutritional balance are important for human health,and the irrational diet is closely related to the high incidence of chronic diseases.Precision nutrition aims to provide safe and efficient nutritional intervention according to individual background characteristics,improve dietary imbalance,maintain human health,and effectively prevent and control diseases.Functional factors in food can regulate human function by activating enzyme activity or other ways,which is an important material basis for precision nutrition and an important means for nutritional regulation.Aiming at the problems of poor solubility,stability and bioavailability of functional factors,the establishment of the steady-state targeted delivery system helps to improve the stability and bioavailability of functional factors,realize the controlled release of targeted action sites in vivo,and provide the pathways and methods of nutritional intervention for precision nutrition.In this paper,the key links between precision nutrition and life and health,the promotion effect of targeted delivery of food functional factors on the realization of precision nutrition,and the bottleneck problems were summarized,and the current situation of steady-state targeted delivery and controlled release of functional factors,as well as the internal relationship and important role of precision nutrition was discussed.The steady-state targeted delivery of active peptides,unsaturated fatty acids,polyphenols,and carotenoids,as well as their nutritional intervention effects on inflammatory bowel disease,cancer,alcoholic fatty liver,atherosclerosis,and obesity were introduced in detail.The development trends,opportunities,and challenges of precision nutrition industry in China were summarized and prospected,aiming to provide reference for steady-state targeted delivery of food functional factors to boost and promote the scientific research and industrial application of food functional factors.