植物多酚的抗炎功效及微胶囊化研究进展

Research Progress on Anti-inflammatory Activity and Microencapsulation of Plant Polyphenols

植物多酚是一类具有多个酚羟基的次生代谢产物,广泛分布于植物中。因多酚具有抗炎等多种生理功能,对人体健康具有潜在益处,故成为近年来的研究热点之一。由于环境等因素的影响,多酚的稳定性降低,可能影响其抗炎功效,而利用微胶囊技术对多酚进行包埋,可使其在较长时间内保持生物活性。本文从细胞模型及动物模型2个方面对多酚的抗炎功能进行综述,并概述多酚的抗炎机制以及多酚微胶囊的研究进展,旨在为植物多酚的进一步利用和抗炎药物开发提供理论参考。

Plant polyphenols,which are widely presented in plants,are a class of natural secondary metabolites with multiple phenolic hydroxyl groups.Plant polyphenols have become one of the hot topics in recent years due to its potential health benefits and various physiological functions such as anti-inflammatory.Nonetheless,the stability of polyphenols will be reduced due to the environmental conditions,thus affecting their anti-inflammatory activity.Microencapsulation technology could encapsulate polyphenol into carriers and keep it biologically active for a longer period of time.This paper reviewed the anti-inflammatory functions of polyphenols in cell models and animal models and the anti-inflammatory mechanisms.Moreover,the research progress of polyphenol microcapsules was also reviewed,aiming at providing a theoretical reference for the further utilization of plant polyphenols and anti-inflammatory drug development.