干细胞治疗在角膜重建中的研究进展

Research progress of stem cell therapy in corneal reconstruction

外伤、感染、先天性疾病等均可能破坏角膜的组织结构和细胞稳态,同时造成角膜干细胞缺损,进而导致组织无法正常愈合,引起角膜盲,是世界范围内致盲的重要原因之一。目前已有多种干细胞相关的技术方法应用于重建功能性角膜组织,取得了瞩目的治疗效果。本综述以角膜缘干细胞缺乏症为主,旨在介绍多种来源的干细胞在角膜重建中的研究现状和最新进展,同时对不同干细胞的特异性标志物的研究进展进行阐述。

Trauma,infection and congenital diseases may disrupt the tissue structure and cellular homeostasis of the cornea,while causing impaired function of corneal stem cell defects,which in turn may even lead to corneal blindness caused by the inability of the tissue to heal properly.Corneal blindness is one of the major causes of blindness worldwide.Several stem cell-related techniques have been applied to reconstruct functional corneal tissue with impressive therapeutic results.This review focuses on corneal limbal stem cell deficiency and aims to present the current status and recent progress of research on stem cells from multiple sources in corneal reconstruction,as well as to describe specific markers of corneal stem cells.