基于关联规则及因子分析中药治疗便秘型肠易激综合征的用药规律

The Medication Rule of Traditional Chinese Medicine in the Treatment of Constipation-type Irritable Bowel Syndrome Based on Association Rule and Factor Analysis

目的探讨治疗便秘型肠易激综合征(IBS-C)的用药规律,为中药治疗IBS-C提供参考及借鉴。方法检索建库至2020年12月中国知网(CNKI)、维普数据库(VIP)、万方数据库及中国生物医学文献数据库(CBM)发表的中药治疗IBS-C的相关文献。采用Excel 2019表格分析药物的频次、四气、五味及归经;SPSS Modeler 18.0软件进行组方规律分析、SPSS Statistics 26.0进行药物的因子分析和聚类分析,探讨IBS-C的临床用药规律。结果纳入文献111篇,涉及处方117首。外方中药物药性以温、寒、平为主;苦、辛、甘味药物使用频次最高;主归脾、胃、肺、肝、大肠经。关联规则分析发现24对关联强度高的药对,常用药对有白芍-甘草、白芍-白术-柴胡等。结论因子分析提取8个公因子,系统聚类分析归为4类。

Objective To explore the rule of effective Chinese medicine in the treatment of constipation-type irritable bowel syndrome(IBSC).Methods Literature related to traditional Chinese medicine(TCM)treatment of IBS-C published in China National Knowledge Infrastructure(CNKI),VIP database,Wanfang database and China Biomedical Literature Database(CBM)was retrieved from the database establishment to December 2020.Excel 2019 table was used to analyze the frequency,four nature of drugs,five flavors and meridian return of the drugs.SPSS Modeler18.0 software was used to analyze the rule of prescription,and SPSS Statistics 26.0 was used to analyze the factor analysis and cluster analysis of drugs to explore the rule of clinical drug use of IBS-C.Results A total of 111 literatures were included,including 117 prescriptions,which contained 125 TCM flavors.Among them,the medicinal properties were mainly warm,cold and flat.The drug use frequency of bitter,octyl and glycine was the highest,and mainly belongs to spleen,stomach,lung,liver,large intestine meridian.In association rule analysis,it was found that the combination of drug pairs with the highest association intensity was 24 pairs,and the common drug pairs were Paeonia-Licorice,Paeonia-Atractylodes and Bupleurum,etc.Conclusion Eight common factors were extracted by factor analysis,which were classified into four categories by systematic cluster analysis.