基于专利数据研究中药复方治疗慢性萎缩性胃炎的用药规律

Medication Rules of Traditional Chinese Medicine Patent Compounds for Chronic Atrophic Gastritis Based on Data Ming

目的:通过专利分析,挖掘慢性萎缩性胃炎中药复方用药规律。方法:检索国家知识产权局专利库中治疗慢性萎缩性胃炎的中药专利复方数据,使用中医传承辅助平台统计药物使用频次,分析关联规则,构建复杂网络等。结果:纳入专利复方189条,高频药物有白术、甘草等。药性以温、寒、平居多,药味以苦、甘、辛多见,归经以脾、胃、肝经为主。最常用对药为“白术-茯苓”;最常用角药为“延胡索-白术-白芍”;高置信度关联规则有“甘草,茯苓→白术”等;熵层次聚类新处方有“厚朴-枳实-鸡内金-茵陈”等。结论:慢性萎缩性胃炎以脾胃虚弱为基本病机,以虚实夹杂为病理特点,以血瘀为重要病理趋势,治疗应以健脾益气为基础治法,重视活血化瘀法以求病理机转。

Objective:To study the medication rule of traditional Chinese medicine(TCM)compounds in the treatment of chronic atrophic gastritis.Methods:The patent library of China National Intellectual Property Administration was searched to obtain the patent data of TCM compound for treating chronic atrophic gastritis.Then the data were imported into the Traditional Chinese Medicine Inheritance Support System(V2.5)for frequency statistics,association rule analysis,and complex network construction.Results:A total of 189 TCM patent compounds were included.The high-frequency Chinese medicinal materials were Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae.The medicinal materials were mainly warm,cold,moderate in property,and bitter,sweet,pungent in flavor,and mainly acted on spleen,stomach,and liver.The most common drug pair and triple drug combination were Rhizoma Atractylodis Macrocephalae-Poria and Rhizoma Corydalis-Rhizoma Atractylodis Macrocephalae-Radix Paeoniae Alba,respectively.The association rule with high confidence was Radix Glycyrrhizae,Poria→Rhizoma Atractylodis Macrocephalae,and the new obtained prescription via entropy-based hierarchical clustering was Cortex Magnoliae Officinalis-Fructus Aurantii Immaturus-Endothelium Corneum Gigeriae Galli-Herba Artemisiae Scopariae.Conclusion:The basic pathogenesis of chronic atrophic gastritis was deficiency of spleen and stomach,with deficiency-excess in complexity as the pathological characteristics and blood stasis as the important disease trend.The treatment should be based on invigorating spleen and replenishing qi and focus on activating blood and resolving stasis.