CysC、SCr、BUN在肾病患者外周血中的检测意义

The Significance of Detections of CysC,SCr and BUN inPeripheral Blood of Patients with Nephropathy

目的探讨胱抑素C(CysC)、血尿素氮(BUN)、血肌酐(SCr)在肾病患者外周血中的检测意义。方法选取衡水市中医医院内分泌肾病科2020年10月至2021年10月诊治的90例脾肾气虚型膜性肾病患者,按照疾病进展分为脾肾气虚型膜性肾病Ⅰ期32例为A组,脾肾气虚型膜性肾病Ⅱ期30例为B组,脾肾气虚型膜性肾病Ⅲ期28例为C组,另外选取同期在我院体检的健康者30例为对照组,检测各组的CysC、SCr、BUN水平,并且比较CysC、SCr、BUN水平免疫指标关系。结果(1)各组的CysC、SCr、BUN水平随着疾病预后结果的下降显著升高,且差异均具有统计学意义(P<0.05);(2)3组患者的疾病预后结果与CysC、SCr、BUN水平呈负相关,且差异均具有统计学意义(P<0.05);(3)对照组血清总补体活性(CH50)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、血清补体C_(3)、血清补体C_(4)高于A组、B组、C组(P<0.05),免疫球蛋白E(IgE)、红细胞沉降率(ESR)、C反应蛋白(CRP)低于A组、B组、C组(P<0.05)。结论对于肾病患者而言,随着疾病的预后结果的下降,CysC、SCr、BUN水平显著升高。

Objective To investigate the significance of detections of cystatin C(CysC),blood urea nitrogen(BUN)and serum creatinine(SCr)in peripheral blood of patients with renal diseases.Methods We selected90patients with membranous nephropathy of spleen-kidney qi deficiency type diagnosed and treated by the Department of Endocrinology and Nephrology of Hengshui Traditional Chinese Medicine Hospital from October,2020 to October,2021,and divided them into stage Ⅰ membranous nephropathy of spleen-kidney qi deficiency type according to disease progression.32 cases were included in Group A,while 30 cases of membranous nephropathy of spleen-kidney qi deficiency type Ⅱ stage were included in group B,and28 cases of membranous nephropathy of spleen-kidney qi deficiency type Ⅲ stage were included in group C.In addition,30 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.CysC,SCr,and BUN levels of these groups were compared,and the relationship between CysC,SCr,and BUN levels of the immune indexes was evluated.Results(1)Levels of CysC,SCr,and BUN in each group increased significantly with the decline of the disease prognosis,and the differences were statistically significant(P <0.05);(2)The disease prognosis of three groups was significantly different among CysC,SCr,and BUN and the levels were negatively correlated,and the differences were statistically significant(P<0.05);(3)For the control group,serum total complement activity(CH50),immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),serum complement C3,and serum complement C4 were higher than those in group A,group B,and group C(P<0.05),while immunoglobulin E(IgE),erythrocyte sedimentation rate(ESR),and C-reactive protein (CRP)were lower than those in group A,group B,and group C(P<0.05).Conclusion In the peripheral blood of patients with nephropathy,levels of CysC,SCr and BUN increase significantly with the decline of the prognostic effect of the disease.