曲安奈德应用于口腔扁平苔藓的不良反应及其应对策略的研究进展

Research progress on the adverse reactions of triamcinolone acetonide in oral lichen planus and its countermeasures

口腔扁平苔藓(OLP)是一种常见的慢性炎症性口腔黏膜疾病,与机体的免疫缺陷密切相关。曲安奈德因其抗炎、抗过敏和免疫抑制的功能,被认为是治疗OLP的首选药物,但长期应用曲安奈德会产生多种不良反应,且停药后易出现反跳现象,这极大地限制了OLP的临床治疗。本文就曲安奈德治疗口腔扁平苔藓的不良反应及其应对策略作一综述,以期为临床治疗OLP提供参考。

Oral lichen planus(OLP)is a common chronic inflammatory oral mucosa disease,which is closely related to immune deficiency.Triamcinolone acetonide is considered to be the drug of choice for treatment of OLP due to its anti-inflammatory,anti-allergic and immunosuppressive effects.However,long-term application of triamcinolone acetonide can produce a variety of adverse reactions,and it prone to rebound after discontinuation,which greatly hinders the clinical diagnosis and treatment of OLP.This article reviews the adverse reactions of triamcinolone acetonide in the treatment of OLP and its coping strategies in order to provide some reference for the clinical treatment of OLP.