SIRT1在代谢相关脂肪性肝病中的作用及其运动的改善效应

The Role of SIRT1 in Metabolic Associated Fatty Liver Disease and the Ameliorative Effects of Exercise

SIRT1是一种细胞能量传感器,通过去乙酰化多种转录因子和调节蛋白在代谢健康中发挥重要作用.SIRT1的药理性激活可以调节肝脏脂质代谢,减轻代谢相关脂肪性肝病(metabolic associated fatty liver disease, MAFLD)的严重程度,包括发病、进展和并发症.SIRT1在MAFLD患者和高脂饮食喂养小鼠的肝脏中被下调,体育锻炼是MAFLD的一种有效的非药物疗法,定期运动可恢复并激活MAFLD患者肝脏SIRT1水平,使细胞代谢过程正常化.运动打破全身能量稳态,SIRT1是细胞能量代谢的重要调节剂,因此,进一步研究运动引起SIRT1上下游信号通路的变化可能找到代谢性疾病治疗的新靶点,旨在为MAFLD的临床康复提供新思路.

SIRT1 is a cell energy sensor which plays an important role in metabolic health by deacetylating a variety of transcription factors and regulatory proteins. The pharmacological activation of SIRT1 can regulate liver lipid metabolism and reduce the severity of metabolic associated fatty liver disease(MAFLD) including onset, progression and complications. SIRT1 is down regulated in the liver of MAFLD patients and HFD fed mice. Physical exercise is an effective non-drug therapy for MAFLD. Regular exercise can restore and activate the level of SIRT1 in the liver of MAFLD patients and normalize the process of cell metabolism. Exercise breaks the holistic energy homeostasis, and SIRT1 is an important regulator of cell energy metabolism. Therefore, further study on the changes of upstream and downstream signal pathways of SIRT1 caused by exercise may find new targets for the treatment of metabolic diseases, in order to provide new ideas for the clinical rehabilitation of MAFLD.