基于倾向性评分匹配的慢性阻塞性肺疾病影响因素研究

Study on influencing factors of chronic obstructive pulmonary disease based on propensity score matching

目的经倾向性评分匹配(propensity score matching,PSM)均衡组间人口学特征后,研究慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)与生活行为习惯、个体疾病等因素的关系。方法使用2014-2015年山西省居民COPD监测数据,其中病例组277人,对照组1795人。采用PSM按1∶1选取在人口学特征上与病例相近的对照个体;采用条件Logistic回归分析模型分析COPD的影响因素。结果成功匹配275对,条件Logistic回归分析模型结果显示,知晓COPD者患病风险降低了92.8%;既往经常咳嗽、有呼吸道疾病史、接触有害气体、吸烟者患COPD的风险分别提高了1.489倍、1.371倍、1.013倍、0.834倍。结论加强COPD的健康教育、禁烟、不接触有害气体、及时治疗呼吸系统疾病是预防和减少COPD发生的重要措施。

Objective To study the relationship between COPD and living habits,individual diseases,based on balanced demographic confounding factors between the case group and the control group by the PSM.Methods Data from 2014 to 2015 on COPD surveillance were first employed among residents of Shanxi Province,including 277 patients in the case group and 1795 in the control group.Afterwards,275 randomly matched control subjects were selected using PSM in a ratio of 1∶1.Besides,conditional Logistic regression was utilized to study the influencing factors of COPD.Results The conditional Logistic regression results,based on 275 successfully matched pairs,showed a 92.8%reduction in the risk of developing COPD among those who knew about it;the risk of developing COPD was increased by 1.489 times,1.371 times,1.013 times and 0.834 times among those with previous frequent coughing,respiratory disease,exposure to harmful gases and smoking respectively.Conclusions Better health education,smoking ban,no exposure to harmful gases and timely treatment of respiratory diseases are important measures to prevent and reduce the occurrence of COPD.