艾拉莫德联合甲氨蝶呤治疗类风湿关节炎的疗效及安全性

Efficacy and safety of allamod combined with methotrexate in the treatment of rheumatoid arthritis

目的观察艾拉莫德联合甲氨蝶呤治疗类风湿关节炎的疗效及安全性。方法选取2020年4月—2021年4月广东省肇庆市第一人民医院收治的类风湿关节炎患者80例,按照随机数字表法分为研究组与对照组,每组40例。对照组实施甲氨蝶呤治疗,研究组实施艾拉莫德联合甲氨蝶呤治疗,2组均治疗24周。比较2组患者的临床疗效,治疗前后晨僵时间、关节压痛数、关节肿胀数、实验室指标及不良反应。结果研究组患者ACR20有效率、ACR50有效率、ACR70有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗24周后,2组患者晨僵时间均缩短,关节压痛数及关节肿胀数均减少,且研究组短/少于对照组,差异均有统计学意义(P<0.05);2组患者的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)水平均降低,且研究组低于对照组,差异均有统计学意义(P<0.01)。对照组与研究组患者不良反应总发生率比较差异无统计学意义(20.00%vs.12.50%,χ^(2)=0.827,P=0.363)。结论艾拉莫德联合甲氨蝶呤治疗类风湿关节炎可促进症状改善,减轻机体炎性反应,安全性良好,临床价值显著。

Objective To observe the efficacy and safety of alamud combined with methotrexate in the treatment of rheumatoid arthritis.Methods A total of 80 patients with rheumatoid arthritis admitted to the First People′s Hospital of Zhaoqing,Guangdong Province from April 2020 to April 2021 were selected and divided into study group and control group according to random number table method,40 patients in each group.The control group was treated with methotrexate,and the study group was treated with alamud combined with methotrexate,both groups were treated for 24 weeks.The clinical efficacy,morning stiffness time,joint tenderness,joint swelling,laboratory indicators before and after treatment and adverse reactions were compared between 2 groups.Results The effective rate of ACR20,ACR50 and ACR70 in study group were higher than that in control group,with statistical significance(P<0.05).After 24 weeks of treatment,morning stiffness time were shortened,joint tenderness and joint swelling were reduced in 2 groups,and the length in the study group was shorter/less than that in the control group,the differences were statistically significant(P<0.05).The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and vascular endothelial growth factor(VEGF)in 2 groups were decreased,and the study group was lower than the control group,the differences were statistically significant(P<0.01).There was no significant difference in the total incidence of adverse reactions between control group and study group(20.00%vs.12.50%,χ^(2)=0.827,P=0.363).Conclusion In the treatment of rheumatoid arthritis,alamud combined with methotrexate can promote the improvement of symptoms and reduce the inflammatory response of the body,with good safety and significant clinical value.