胶质淋巴系统--脑部疾病机制研究新方向

Glymphatic System:a New Research Direction for the Pathogenesis of Brain Diseases

胶质淋巴系统是一个主要由星形胶质细胞水通道蛋白4介导的依靠动脉、静脉周围血管间隙的脑脊液-脑组织液交换流动的系统,是阿尔茨海默病、脑卒中、帕金森病、失眠、抑郁症等脑病的共同特征,是一条新的脑代谢途径,可以清除包括β-淀粉样蛋白、乳酸在内的代谢产物。本文综合分析了全球有关胶质淋巴系统在脑部疾病的研究,得出:胶质淋巴系统可能为神经退行性疾病等发病机制和诊治策略研究带来新视角;胶质淋巴系统有望为一些脑部疾病诊断提供新的有效证据;胶质淋巴系统可能是脑部疾病治疗给药方式的新途径。

The glymphatic system is mainly mediated by aquaporin 4 on astrocytes and relies on the exchange and flow of cerebrospinal fluid and brain tissue fluid in the vascular space around arteries and veins.It is a common feature of encephalopathy such as Alzheimer's disease,stroke,Parkinson's disease,insomnia,depression.It is a new brain metabolic pathway that can remove metabolites includingβ-amyloid and lactate.This paper comprehensively analyzes the global research on the glial lymphatic system in brain diseases,and concludes that the glial lymphatic system may bring a new perspective for the study of the pathogenesis and diagnosis and treatment strategies of neurodegenerative diseases;glial lymphatic system is expected to provide new and effective evidence for the diagnosis of some brain diseases;the glial lymphatic system may be a new way to treat brain diseases.