小胶质细胞在阿尔茨海默病神经炎性反应中作用的研究进展

Function of the microglia in neuroinflammation of Alzheimer’s disease:a brief review

阿尔茨海默病(AD)患者脑区存在不同分型的激活小胶质细胞。随神经炎性反应进展,这些细胞存在明显形态学和功能变化。它们通过改变细胞吞噬功能、参与免疫反应、或诱导胞内毒性反应来发挥致病作用。针对小胶质细胞在AD神经炎性反应中的作用,目前已开展一系列临床药物实验来推进靶向治疗。亟需更多研究来阐明小胶质细胞在AD神经炎性反应中的作用和机制。

Different types of activated imbroglio exist in the brain of the patients with Alzheimer’s disease(AD). As the neuroinflammation reaction progresses, significant changes take place in the morphology and function of those cells. They could play a pathogenic role by altering the phagocytic function of cells, including intracellular toxic reactions or directly participate in immune response. Several clinical trials have been conducted to promote targeted therapy focusing on the role that microglia played in neuroinflammation reactions of AD. More large scale studies are necessary to elucidate the function and mechanism of microglia in the neuroinflammation reaction of AD.