无创心输出量监测联合米力农注射液治疗重症肺炎合并心力衰竭患者的效果

Effect of Noninvasive Cardiac Output Monitoring Combined with Milrinone Injection in the Treatment of Patients with Severe Pneumonia Complicated with Heart Failure

目的:探讨无创心输出量监测联合米力农注射液治疗重症肺炎合并心力衰竭患者的效果。方法:选取2019年1月-2021年1月来广州市红十字会医院进行治疗的86例重症肺炎合并心力衰竭患者。根据随机数字法将其分为研究组和对照组,各43例。两组均接受无创心输出量监测,对照组采用常规治疗及多巴胺,研究组在对照组的基础上采用米力农注射液治疗。比较两组治疗前后的动脉血气指标、心功能指标、炎症因子及不良反应。结果:治疗后,研究组动脉氧分压(PaO)高于对照组,而动脉二氧化碳分压(PaCO)低于对照组(P<0.05)。治疗后,研究组脑钠肽(BNP)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平均低于对照组(P<0.05)。治疗后,研究组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、CRP水平均低于对照组(P<0.05)。研究组不良反应发生率低于对照组(P<0.05)。结论:在重症肺炎合并心力衰竭患者中,采用无创心输出量监测联合米力农注射液治疗,具有特别确切的临床效果,可改善患者的动脉血气情况,保护患者的心功能,同时,明显降低炎症因子水平,且不良反应发生率低,安全性高,值得推广。

Objective:To investigate effect of noninvasive cardiac output monitoring combined with Milrinone Injection in the treatment of patients with severe pneumonia complicated with heart failure.Method:A total of 86 patients with severe pneumonia complicated with heart failure who came to Guangzhou Red Cross Hospital for treatment from January 2019 to January 2021 were selected.According to the random number method,they were divided into study group and control group,with 43 cases in each group.Both groups received noninvasive cardiac output monitoring.The control group received routine treatment and Dopamine,and the study group received Milrinone Injection on the basis of the control group.The arterial blood gas indexes,cardiac function indexes,inflammatory factors before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,the arterial partial pressure of oxygen(PaO)in the study group was higher than that in the control group,while the arterial partial pressure of carbon dioxide(PaCO)was lower than that in the control group(P<0.05).After treatment,the levels of brain natriuretic peptide(BNP),cardiac troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)in the study group were lower than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),CRP levels in the study group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion:In patients with severe pneumonia complicated with heart failure,noninvasive cardiac output monitoring combined with Milrinone Injection treatment has a particularly accurate clinical effect,which can improve the arterial blood gas status of patients,protect the cardiac function of patients,and significantly reduce the levels of inflammatory factors,with a low incidence of adverse reactions and high safety.It is worth popularizing.