常规治疗辅以丙种球蛋白对小儿重症腺病毒肺炎的效果及安全性

Efficacy and Safety of Routine Therapy Supplemented with Gamma Globulin in the Treatment of Severe Adenovirus Pneumonia in Children

目的:分析常规治疗辅以丙种球蛋白对小儿重症腺病毒肺炎的临床效果及安全性,为今后临床治疗提供参考依据。方法:选取北京航天总医院2018年1月-2021年1月收治的重症腺病毒肺炎患儿192例,按照数字表随机法分为两组,对照组(n=96)采用常规治疗,观察组(n=96)在此基础上,辅以丙种球蛋白治疗,比较两组临床疗效及安全性。结果:观察组总有效率为91.67%,对照组总有效率为78.13%,观察组总有效率优于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为12.50%,对照组不良反应发生率为9.38%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组住院时间、退热时间、机械通气时间均优于对照组,差异有统计学意义(P<0.05)。观察组免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,差异有统计学意义(P<0.05)。结论:重症腺病毒肺炎患儿采用常规治疗辅以丙种球蛋白的临床效果佳,安全性好,可缩短患儿的恢复时间,提高免疫功能,是一种良好的治疗方案。

Objective:To analyze the clinical efficacy and safety of routine treatment supplemented with gamma globulin in the treatment of severe adenovirus pneumonia in children,and to provide reference for future clinical treatment.Method:A total of 192 cases of children with severe adenovirus pneumonia admitted to Beijing Aerospace General Hospital from January 2018 to January 2021 were randomly divided into two groups according to the number table method.The control group(n=96)received conventional treatment,and the observation group(n=96)was treated with gamma globulin on the basis of control group,and the clinical efficacy and safety of the two groups were compared.Result:The total effective rate of the observation group was 91.67%,and the control group was 78.13%.The total effective rate of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was 12.50%in the observation group and 9.38%in the control group,and there was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).The length of hospital stay,antipyretic time and mechanical ventilation time in observation group were better than those in control group,and the differences were statistically significant(P<0.05).The levels of immunoglobulin M(IgM),immunoglobulin A(IgA),immunoglobulin G(IgG),CD4^(+),CD4^(+)/CD8^(+)in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Conclusion:Routine treatment supplemented with gamma globulin in children with severe adenovirus pneumonia has good clinical efficacy and safety,which can shorten the recovery time of children and improve the immune function,it is a good treatment plan.