NK细胞治疗和应用于食管鳞状细胞癌的现状和展望

Status and prospect of NK cell therapy and application for esophageal squamous cell carcinoma

食管癌是一种世界范围内常见的消化道恶性肿瘤,根据其病理分型分为食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)和食管腺癌(esophageal adenocarcinoma,EAC),其中ESCC在东亚地区最为多见。近年来,肿瘤免疫治疗为ESCC的治疗提供了新的方向,自然杀伤(natural killer,NK)细胞作为天然免疫系统中重要的淋巴细胞,构成了宿主抵御感染病原体和癌症的第一道防线。本文旨在对NK细胞治疗ESCC的现状作一概述,为ESCC寻求更精准、更有利的治疗方法提供理论基础和思路。

Esophageal cancer is a worldwide common digestive tract malignant tumor.According to pathological classification,it can be divided into esophageal squamous cell carcinoma(ESCC) and esophageal adenocarcinoma(EAC),of which ESCC is most common in East Asia.In recent years,the tumor immunotherapy for the treatment of ESCC provides a new direction.As important lymphocytes in the natural immune system,natural killer(NK) cells constitute the first line of defense against infectious pathogens and cancer.This review aimed to give an outline of NK cells in the treatment of ESCC,searching for more accurate,favourable treatment for ESCC and to provide theoretical basis and train of thought.