终末期肝病肌少症发生机制的研究进展

Research progress on the pathogenesis of sarcopenia in end-stage liver disease

肌肉减少症(肌少症,Sarcopenia)是终末期肝病的严重并发症之一,主要表现为肌肉的质量下降和功能减退,但因其隐匿性与低认识度通常被临床工作者忽视。终末期肝病肌少症的发生涉及到多种机制,诸如各种分子靶点、信号通道、营养与代谢异常及肠道微生态等。肌少症在终末期肝病发病率较高,且与终末期肝病患者的预后密切相关。因此,了解终末期肝病中肌少症的发生机制对其认识、治疗及预后具有重要意义。

Sarcopenia is one of the serious complications of end-stage liver disease,which is mainly manifested by decreased muscle quality and function.And it is usually ignored by clinical workers because of its insidiousness and low awareness.The occurrence of sarcopenia in end-stage liver disease involving in various mechanisms,such as kinds of molecular targets,signal channels,nutritional and metabolic abnormalities,and intestinal microecology.Sarcopenia has a high incidence in end-stage liver disease which is closely related to the prognosis of patients with end-stage liver disease.Therefore,understanding of sarcopenia mechanism in the end-stage liver disease on the awareness,treatment and prognosis is of great significance.