反流性食管炎的检出率及分级构成的变迁

Detection rate of reflux esophagitis and the change of grading composition

目的探索反流性食管炎的检出率及分级构成的变迁。方法回顾性分析华东医院2006年1月至2008年12月及2016年1月至2018年12月,2个时段经胃镜确诊为反流性食管炎(RE)患者的年龄、性别、内镜下分级等资料,比较分析2个时段RE的年龄及性别分布、RE内镜下分级构成的差异。结果2个时段RE总检出率为12.61%,其中2006年1月至2008年12月RE检出率为9.13%,2016年1月至2018年12月RE的检出率为13.87%,显著高于前一时段(P<0.001)。2个时段的男性RE总检出率为17.30%,女性为8.30%,男性显著高于女性(P<0.001),2个时段这一特征类似。2006年1月至2008年12月老年人RE检出率为10.17%,高于中青年人RE检出率的8.53%(P<0.001);但2016年1月至2018年12月中青年RE检出率为13.63%,老年RE检出率为14.12%,差异无统计学意义(P=0.117)。2个时段中RE分级的构成比由高到低:A级>B级>C级>D级,中重度RE多见于老年人,这一特点没有变化,但与2006年1月至2008年12月比较,2016年1月至2018年12月轻度RE明显更高,中重度RE相对更少(P<0.001)。结论随着时间的推移,反流性食管炎的检出率越来越高,其内镜特征也发生了某些变化,值得临床重视。

Objective To investigate the detection rate of reflux esophagitis and the change of grading composition.Methods The data of age,gender,endoscopic grading,etc.of patients with reflux esophagitis(RE)diagnosed by gastroscopy in Huadong Hospital in two periods from January 2006 to December 2008 and from January 2016 to December 2018 were retrospectively analyzed.The age and gender distribution of RE and the difference of endoscopic grading composition of RE in the two periods were compared and analyzed.Results The total detection rate of RE in the two periods was 12.61%,of which the detection rate of RE from 2016 to 2018 was 13.87%,significantly higher than 9.13%in the previous period from January 2006 to December 2008(P<0.001).The total detection rate of RE in men in the two periods was 17.30%,significantly higher than 8.30%in women(P<0.001).This feature was similar in the two periods.From January 2006 to December 2008,the detection rate of RE in the elderly was 10.17%,higher than 8.53%in the young and middle-a g e d(P<0.001).However,from January 2016 to December 2018,the detection rate of RE in the young and middle-aged was 13.63%,and that in the elderly was 14.12%,with no statistically significant difference(P=0.117).In the 2 periods,the composition ratio of RE grading ranged from high to low was Grade A>Grade B>Grade C>Grade D.Moderate and severe RE was more common in the elderly,and this feature had not changed.However,compared with January 2006 to December 2008,mild RE increased significantly from January 2016 to December 2018,while moderate and severe RE decreased(P<0.001).Conclusion With the passage of time,the detection rate of RE is getting higher,and its endoscopic features have a certain change,which is worthy of clinical attention.