铁蓄积对绝经后骨质疏松症的影响

Influence of iron accumulation on postmenopausal osteoporosis

铁蓄积与骨质疏松症发生发展存在相关性,许多研究认为铁蓄积是绝经后骨质疏松症一个独立危险因素。铁蓄积是指人体血清铁蛋白高于正常值而<1000μg/L的一种特殊状态;基础研究已提出铁蓄积可改变成骨细胞、破骨细胞等功能的相关机制,临床研究亦提示部分绝经后女性铁蛋白水平增加与骨量下降存在相关性。因此,重视铁蓄积对绝经后骨质疏松症的影响,对该领域进一步深入机制研究、成果转化具有重要意义:铁蓄积影响骨代谢是否有独立靶点、可干预机制?部分绝经后骨质疏松患者是否可采用降铁疗法,形成个体化防治方案?本文根据时间线梳理国内外研究进展、分析近10年铁蓄积与骨质疏松症相关研究结果,在为绝经后骨质疏松症相关研究、临床防治提供一些启发。

Iron accumulation is closely related to the occurrence and development of osteoporosis,and it s regarded as an independent risk factor of postmenopausal osteoporosis.Iron accumulation refers to a state of human in which serum ferritin is higher than the normal value but less than 1000μg/L.Basic research suggests that iron accumulation can change the functions of osteoblasts,osteoclasts and affect bone metabolism.Related clinical studies also indicate that ferritin levels are associated with bone loss,and it s meaningful for in-depth mechanism research and achievement transformation in this field:Is there an independent target and intervention mechanism for iron accumulation to affect bone metabolism?Can some postmenopausal patients with osteoporosis be treated with iron-reducing methods?This article summarizes the research on iron accumulation and osteoporosis in the past 10 years to provide some inspiration for the mechanism research,and prevention and treatment strategies of postmenopausal osteoporosis.