Ⅰ期肺癌患者术后复发的影响因素分析

Influencing factors of postoperative recurrence in patients with stage Ⅰ lung cancer

目的分析Ⅰ期肺癌患者术后复发的影响因素。方法回顾性收集2016—2018年邯郸市中心医院收治的147例行肺癌根治术的Ⅰ期肺癌患者的临床资料。电话随访2年,统计患者术后复发情况,记录患者1、2年累积生存率。采用多因素Logistic回归分析Ⅰ期肺癌患者术后复发的影响因素。结果147例患者中,复发19例,复发率为12.9%;1年累积生存率为95.2%,2年累积生存率为88.4%。单因素分析结果显示,不同分化程度、肿瘤最大直径、清扫淋巴结数目及有无肺膜转移、吸烟史、毛刺征象的患者术后复发率比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,有肺膜转移、有毛刺征象是Ⅰ期肺癌患者术后复发的独立危险因素,低分化、肿瘤最大直径≤2.5 mm、清扫淋巴结数目≥12个是其术后复发的保护因素(P<0.05)。结论有肺膜转移、毛刺征象是Ⅰ期肺癌患者术后复发的独立危险因素,低分化、肿瘤最大直径≤2.5 mm、清扫淋巴结数目≥12个是其术后复发的保护因素。

Objective To analyze the influencing factors of postoperative recurrence in patients with stage Ⅰ lung cancer. Methods The clinical data of 147 patients with stage Ⅰ lung cancer received in Handan Central Hospital from 2016to 2018 were retrospectively collected. Following-up for 2 years by telephone,incidence of postoperative recurrence was counted,and the cumulative survival rate was recorded. Multivariate Logistic regression analysis was used to analyze the influencing factors of postoperative recurrence of stage Ⅰ lung cancer patients. Results There were 19 cases of recurrence in147 patients,the recurrence rate was 12. 9%. The 1-year cumulative survival rate was 95. 2% and the 2-year cumulative survival rate was 88. 4%. Multivariate Logistic regression analysis showed that pulmonary membrane metastasis,burr sign were risk factors of postoperative recurrence of stage Ⅰ lung cancer patients,poorly differentiated,maximum diameter of tumor≤2. 5 mm,number of lymph nodes cleaned≥12 were protective factors of postoperative recurrence of stage Ⅰ lung cancer patients( P < 0. 05). Conclusion Pulmonary membrane metastasis,burr sign are risk factors of postoperative recurrence of stage Ⅰ lung cancer patients,poorly differentiated,maximum diameter of tumor≤2. 5 mm,number of lymph nodes cleaned≥12 are protective factors of postoperative recurrence of stage Ⅰ lung cancer patients.