新生化颗粒辅助治疗稽留流产的临床效果

Clinical effect of Xinshenghua granule on missed abortion

目的 观察新生化颗粒辅助治疗稽留流产的临床效果。方法 回顾性分析2015年8月—2020年1月湖北省红安县人民医院收治的稽留流产患者100例临床资料,根据用药方案不同分为观察组和对照组,各50例。对照组常规予米非司酮+米索前列醇方案治疗,观察组在对照组基础上加用新生化颗粒,2组均连续治疗1周。比较2组临床效果,治疗前后血液流变学指标[红细胞聚集指数、血液黏度、雌二醇(E)及孕酮(P)]变化,相关症状表现(阴道出血时间及出血量)及不良反应。结果 观察组患者治疗总有效率为92.00%,高于对照组的74.00%(χ^(2)=5.741,P=0.017);治疗1周后,2组红细胞聚集指数、血液黏度、E、P水平均较治疗前下降,且观察组低于对照组(P均<0.01);观察组阴道出血时间短于对照组,出血量少于对照组(P均<0.01);观察组不良反应总发生率为8.00%,低于对照组的24.00%(χ^(2)=4.762,P=0.029)。结论 新生化颗粒辅助治疗稽留流产的临床效果显著,可有效改善血液流变学水平,改善症状表现,且药物不良反应发生风险更低,值得临床推广应用。

Objective To observe the clinical effect of Xinshenghua granule on missed abortion. Methods The clinical data of 100 patients with missed abortion treated in Hong’an County People’s Hospital of Hubei Province from August2015 to January 2020 were retrospectively analyzed. They were divided into observation group and control group,with 50 cases in each group according to different medication schemes. The control group was treated with mifepristone + misoprostol,and the observation group was treated with Xinshenghua granule on the basis of the control group. Both groups were treated for 1week. The clinical effects and changes of hemorheological indexes before and after treatment were compared between the two groups,including erythrocyte aggregation index,blood viscosity,estradiol( E) and progesterone( P). The related symptoms( vaginal bleeding time and amount) and adverse reactions between the two groups were also compared. Results The total effective rate of the observation group was 92. 00%,higher than 74. 00% of the control group( χ^(2)~2= 5. 741,P = 0. 017). After one week of treatment,the erythrocyte aggregation index,blood viscosity,Eand P levels in the two groups decreased compared with those before treatment,and the levels in the observation group were lower than those in the control group( all P < 0. 01). The time of vaginal bleeding in the observation group was shorter than that in the control group,and the amount of bleeding was less than that in the control group( all P < 0. 01). The total incidence of adverse reactions in the observation group was 8. 00%,lower than 24. 00% in the control group( χ^(2)~2= 4. 762,P = 0. 029). Conclusion The clinical effect of Xinshenghua granule in the adjuvant treatment of missed abortion is remarkable. It can effectively improve the level of Hemorheology and symptoms,and the risk of adverse drug reactions is lower,which is worthy of clinical application.